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STRINGSTRING
GAGE1 GAGE1 CTAG1A CTAG1A GAGE12F GAGE12F CSAG1 CSAG1 MAGEA2B MAGEA2B TP53 TP53 MAGEA3 MAGEA3 MAGEA2 MAGEA2 CTAG1B CTAG1B CTAG2 CTAG2 GAGE2A GAGE2A
"MAGEA2B" - Melanoma antigen family A, 2B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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MAGEA2BMelanoma antigen family A, 2B; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal d [...] (314 aa)    
Predicted Functional Partners:
CSAG1
Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1 (78 aa)
      
   
  0.793
MAGEA2
Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal d [...] (314 aa)
      
     
0.731
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] (393 aa)
        
 
  0.723
GAGE2A
G antigen 2A (116 aa)
      
   
  0.708
GAGE1
G antigen 1; Belongs to the GAGE family (117 aa)
      
   
  0.703
MAGEA3
Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MA [...] (314 aa)
      
   
0.679
GAGE12F
G antigen 12F; Belongs to the GAGE family (117 aa)
      
   
  0.655
CTAG2
Cancer/testis antigen 2 (210 aa)
      
   
  0.649
CTAG1A
Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family (180 aa)
      
   
  0.648
CTAG1B
Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family (180 aa)
      
   
  0.645
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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