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  • 11.0 [archived version]
STRINGSTRING
PARPBP PARPBP ZBTB7C ZBTB7C C1orf101 C1orf101 GLOD4 GLOD4 GCNT3 GCNT3 AMMECR1 AMMECR1 CCDC60 CCDC60 ZNF438 ZNF438 MYO18B MYO18B MFSD3 MFSD3 FAM32A FAM32A
"CCDC60" - Coiled-coil domain containing 60 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
CCDC60Coiled-coil domain containing 60 (550 aa)    
Predicted Functional Partners:
C1orf101
Cation channel sperm-associated protein subunit epsilon; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization; Belongs to the CATSPERD family (951 aa)
            
  0.805
GLOD4
Glyoxalase domain containing 4 (298 aa)
            
  0.773
ZNF438
Zinc finger protein 438; Isoform 1 acts as a transcriptional repressor; Zinc fingers C2H2-type (828 aa)
            
  0.491
PARPBP
PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect; Belongs to the PARI family (579 aa)
            
  0.490
FAM32A
Protein FAM32A; Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli; Spliceosomal C complex (112 aa)
        
      0.485
MFSD3
Major facilitator superfamily domain containing 3 (412 aa)
            
  0.483
ZBTB7C
Zinc finger and BTB domain-containing protein 7C; May be a tumor suppressor gene; BTB domain containing (619 aa)
            
  0.481
AMMECR1
AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 (333 aa)
            
  0.473
GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development (438 aa)
            
  0.451
MYO18B
Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (2567 aa)
            
  0.446
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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