node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH3A2 | HSD17B13 | ENSP00000345774 | ENSP00000333300 | Fatty aldehyde dehydrogenase; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | 0.512 |
ECI2 | HSD17B13 | ENSP00000369461 | ENSP00000333300 | Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity) | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | 0.565 |
ECI2 | HSD17B4 | ENSP00000369461 | ENSP00000420914 | Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity) | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids; Short chain dehydrogenase/reductase superfamily | 0.887 |
FANK1 | HSD17B13 | ENSP00000357682 | ENSP00000333300 | Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis; Ankyrin repeat domain containing | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | 0.590 |
FRRS1 | HSD17B13 | ENSP00000287474 | ENSP00000333300 | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | 0.473 |
HSD17B13 | ALDH3A2 | ENSP00000333300 | ENSP00000345774 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | Fatty aldehyde dehydrogenase; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.512 |
HSD17B13 | ECI2 | ENSP00000333300 | ENSP00000369461 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity) | 0.565 |
HSD17B13 | FANK1 | ENSP00000333300 | ENSP00000357682 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis; Ankyrin repeat domain containing | 0.590 |
HSD17B13 | FRRS1 | ENSP00000333300 | ENSP00000287474 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family | 0.473 |
HSD17B13 | HSD17B4 | ENSP00000333300 | ENSP00000420914 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids; Short chain dehydrogenase/reductase superfamily | 0.465 |
HSD17B13 | NBPF3 | ENSP00000333300 | ENSP00000316782 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | Neuroblastoma breakpoint family member 3; NBPF member 3; Belongs to the NBPF family | 0.514 |
HSD17B13 | PNPLA3 | ENSP00000333300 | ENSP00000216180 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | Patatin-like phospholipase domain-containing protein 3; Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities; Lipases | 0.498 |
HSD17B13 | SLC16A9 | ENSP00000333300 | ENSP00000378757 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers | 0.468 |
HSD17B13 | SULT4A1 | ENSP00000333300 | ENSP00000332565 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | Sulfotransferase 4A1; Atypical sulfotransferase family member with very low affinity for 3’-phospho-5’-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS; Sulfotransferases, cytosolic | 0.495 |
HSD17B13 | TSPAN10 | ENSP00000333300 | ENSP00000480492 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | Tetraspanin-10; Regulates maturation of the transmembrane metalloprotease ADAM10; Belongs to the tetraspanin (TM4SF) family | 0.680 |
HSD17B4 | ECI2 | ENSP00000420914 | ENSP00000369461 | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids; Short chain dehydrogenase/reductase superfamily | Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity) | 0.887 |
HSD17B4 | HSD17B13 | ENSP00000420914 | ENSP00000333300 | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids; Short chain dehydrogenase/reductase superfamily | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | 0.465 |
NBPF3 | HSD17B13 | ENSP00000316782 | ENSP00000333300 | Neuroblastoma breakpoint family member 3; NBPF member 3; Belongs to the NBPF family | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | 0.514 |
PNPLA3 | HSD17B13 | ENSP00000216180 | ENSP00000333300 | Patatin-like phospholipase domain-containing protein 3; Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities; Lipases | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | 0.498 |
SLC16A9 | HSD17B13 | ENSP00000378757 | ENSP00000333300 | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily | 0.468 |