| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BMP15 | FIGLA | ENSP00000252677 | ENSP00000333097 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | 0.813 |
| BMP15 | GDF9 | ENSP00000252677 | ENSP00000367942 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells; [...] | 0.905 |
| BMP15 | LHX8 | ENSP00000252677 | ENSP00000294638 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells; LIM class homeoboxes | 0.683 |
| BMP15 | NOBOX | ENSP00000252677 | ENSP00000419457 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’; PRD class homeoboxes and pseudogenes | 0.758 |
| BMP15 | POF1B | ENSP00000252677 | ENSP00000262753 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | Protein POF1B; Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development | 0.743 |
| BMP15 | SOHLH1 | ENSP00000252677 | ENSP00000404438 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1; Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development; Basic helix-loop-helix proteins | 0.556 |
| BMP15 | ZP2 | ENSP00000252677 | ENSP00000460971 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | Zona pellucida sperm-binding protein 2; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor | 0.611 |
| BMP15 | ZP3 | ENSP00000252677 | ENSP00000378326 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | Zona pellucida sperm-binding protein 3; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation; Belongs to the ZP domain family. ZPC subfamily | 0.683 |
| FIGLA | BMP15 | ENSP00000333097 | ENSP00000252677 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | 0.813 |
| FIGLA | GDF9 | ENSP00000333097 | ENSP00000367942 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells; [...] | 0.789 |
| FIGLA | LHX8 | ENSP00000333097 | ENSP00000294638 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells; LIM class homeoboxes | 0.862 |
| FIGLA | NOBOX | ENSP00000333097 | ENSP00000419457 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’; PRD class homeoboxes and pseudogenes | 0.881 |
| FIGLA | POF1B | ENSP00000333097 | ENSP00000262753 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Protein POF1B; Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development | 0.748 |
| FIGLA | SOHLH1 | ENSP00000333097 | ENSP00000404438 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1; Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development; Basic helix-loop-helix proteins | 0.804 |
| FIGLA | TCF23 | ENSP00000333097 | ENSP00000296096 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Transcription factor 23; Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity); Basic helix-loop-helix proteins | 0.780 |
| FIGLA | YBX2 | ENSP00000333097 | ENSP00000007699 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5’-UCCAUCA-3’ with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasm [...] | 0.756 |
| FIGLA | ZP2 | ENSP00000333097 | ENSP00000460971 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Zona pellucida sperm-binding protein 2; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor | 0.774 |
| FIGLA | ZP3 | ENSP00000333097 | ENSP00000378326 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | Zona pellucida sperm-binding protein 3; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation; Belongs to the ZP domain family. ZPC subfamily | 0.812 |
| GDF9 | BMP15 | ENSP00000367942 | ENSP00000252677 | Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells; [...] | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins | 0.905 |
| GDF9 | FIGLA | ENSP00000367942 | ENSP00000333097 | Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells; [...] | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E [...] | 0.789 |
