node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA12 | C14orf180 | ENSP00000272895 | ENSP00000333041 | ATP-binding cassette sub-family A member 12; Probable transporter involved in lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | 0.537 |
ABCA12 | ZNF75A | ENSP00000272895 | ENSP00000459566 | ATP-binding cassette sub-family A member 12; Probable transporter involved in lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family | Zinc finger protein 75A; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.449 |
C14orf180 | ABCA12 | ENSP00000333041 | ENSP00000272895 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | ATP-binding cassette sub-family A member 12; Probable transporter involved in lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family | 0.537 |
C14orf180 | CCDC85C | ENSP00000333041 | ENSP00000369592 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | Coiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia | 0.707 |
C14orf180 | DNASE1L3 | ENSP00000333041 | ENSP00000378053 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | Deoxyribonuclease gamma; Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3’-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses ant [...] | 0.621 |
C14orf180 | EGFLAM | ENSP00000333041 | ENSP00000346964 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | Pikachurin; Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity); Fibronectin type III domain containing | 0.577 |
C14orf180 | FLRT2 | ENSP00000333041 | ENSP00000332879 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] | 0.548 |
C14orf180 | LHX4 | ENSP00000333041 | ENSP00000263726 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes | 0.519 |
C14orf180 | NCOA4 | ENSP00000333041 | ENSP00000463027 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | Nuclear receptor coactivator 4; Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma | 0.526 |
C14orf180 | NTNG1 | ENSP00000333041 | ENSP00000359085 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.539 |
C14orf180 | PIGN | ENSP00000333041 | ENSP00000350263 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation; Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily | 0.588 |
C14orf180 | ZNF75A | ENSP00000333041 | ENSP00000459566 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | Zinc finger protein 75A; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.644 |
CCDC85C | C14orf180 | ENSP00000369592 | ENSP00000333041 | Coiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | 0.707 |
CCDC85C | NCOA4 | ENSP00000369592 | ENSP00000463027 | Coiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia | Nuclear receptor coactivator 4; Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma | 0.518 |
DNASE1L3 | C14orf180 | ENSP00000378053 | ENSP00000333041 | Deoxyribonuclease gamma; Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3’-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (By similarity). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses ant [...] | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | 0.621 |
EGFLAM | C14orf180 | ENSP00000346964 | ENSP00000333041 | Pikachurin; Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity); Fibronectin type III domain containing | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | 0.577 |
FLRT2 | C14orf180 | ENSP00000332879 | ENSP00000333041 | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 | 0.548 |
FLRT2 | NTNG1 | ENSP00000332879 | ENSP00000359085 | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] | Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins | 0.404 |
FLRT2 | PIGN | ENSP00000332879 | ENSP00000350263 | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] | GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation; Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily | 0.480 |
FLRT2 | ZNF75A | ENSP00000332879 | ENSP00000459566 | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] | Zinc finger protein 75A; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.454 |