• Version:
  • 11.0 [archived version]
STRINGSTRING
ZNF729 ZNF729 WDTC1 WDTC1 POM121L2 POM121L2 C15orf26 C15orf26 PFN3 PFN3 ACTRT3 ACTRT3 PFN4 PFN4 PPM1L PPM1L LRRC34 LRRC34 MYNN MYNN LRRIQ4 LRRIQ4
"ACTRT3" - Actin related protein T3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACTRT3Actin related protein T3 (372 aa)    
Predicted Functional Partners:
PFN3
Profilin-3; Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis; Belongs to the profilin family (137 aa)
      
 
  0.853
LRRIQ4
Leucine rich repeats and IQ motif containing 4 (560 aa)
        
 
  0.750
MYNN
Myoneurin; Zinc fingers C2H2-type; BTB domain containing (610 aa)
      
 
  0.704
LRRC34
Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro (464 aa)
      
   
  0.683
PFN4
Profilin-4; Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin, contrary to other family members; Belongs to the profilin family (129 aa)
        
 
  0.662
C15orf26
Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly (301 aa)
      
   
  0.563
PPM1L
Protein phosphatase 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6; Protein phosphatases, Mg2+/Mn2+ dependent (360 aa)
      
 
  0.546
WDTC1
WD and tetratricopeptide repeats protein 1; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors (677 aa)
      
   
  0.536
ZNF729
Zinc finger protein 729; May be involved in transcriptional regulation; Zinc fingers C2H2-type (1252 aa)
      
 
  0.525
POM121L2
POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family (1035 aa)
            
  0.520
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >