• Version:
  • 11.0 [archived version]
STRINGSTRING
FBXO39 FBXO39 LYZL1 LYZL1 SPAG8 SPAG8 CCDC73 CCDC73 TEX37 TEX37 NXT2 NXT2 PRSS55 PRSS55 C8orf74 C8orf74 RP1L1 RP1L1 FARSB FARSB SDF2 SDF2
"PRSS55" - Serine protease 55 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRSS55Serine protease 55; Probable serine protease (352 aa)    
Predicted Functional Partners:
FBXO39
F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other (442 aa)
        
 
  0.743
CCDC73
Coiled-coil domain containing 73 (1079 aa)
            
  0.703
TEX37
Testis-expressed sequence 37 protein; Testis expressed 37 (180 aa)
            
  0.694
LYZL1
Lysozyme-like protein 1; Lysozymes, c-type; Belongs to the glycosyl hydrolase 22 family (194 aa)
            
  0.661
RP1L1
Retinitis pigmentosa 1-like 1 protein; Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity); Doublecortin superfamily (2400 aa)
            
  0.657
SPAG8
Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 [...] (501 aa)
            
  0.643
C8orf74
Uncharacterized protein C8orf74; Chromosome 8 open reading frame 74 (294 aa)
            
  0.580
NXT2
NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (197 aa)
            
  0.576
SDF2
Stromal cell derived factor 2 (211 aa)
            
  0.545
FARSB
phenylalanyl-tRNA synthetase beta subunit; Aminoacyl tRNA synthetases, Class II (589 aa)
            
  0.534
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >