| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD109 | CD52 | ENSP00000287097 | ENSP00000363330 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | 0.907 |
| CD109 | CPM | ENSP00000287097 | ENSP00000448517 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | Carboxypeptidase M; Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins; Belongs to the peptidase M14 family | 0.901 |
| CD109 | FOLR2 | ENSP00000287097 | ENSP00000298223 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release | 0.901 |
| CD109 | FOLR4 | ENSP00000287097 | ENSP00000332963 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’. Does not bind folate | 0.903 |
| CD109 | LY6K | ENSP00000287097 | ENSP00000292430 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth; LY6/PLAUR domain containing | 0.903 |
| CD109 | MSLN | ENSP00000287097 | ENSP00000372313 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | Mesothelin; Membrane-anchored forms may play a role in cellular adhesion | 0.925 |
| CD109 | NRN1 | ENSP00000287097 | ENSP00000480483 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | Neuritin; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells | 0.900 |
| CD109 | NRN1L | ENSP00000287097 | ENSP00000342411 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | Neuritin-like protein; Neuritin 1 like | 0.900 |
| CD109 | PRND | ENSP00000287097 | ENSP00000306900 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+); Belongs to the prion family | 0.900 |
| CD52 | CD109 | ENSP00000363330 | ENSP00000287097 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | 0.907 |
| CD52 | CPM | ENSP00000363330 | ENSP00000448517 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | Carboxypeptidase M; Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins; Belongs to the peptidase M14 family | 0.900 |
| CD52 | FOLR2 | ENSP00000363330 | ENSP00000298223 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release | 0.912 |
| CD52 | FOLR4 | ENSP00000363330 | ENSP00000332963 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’. Does not bind folate | 0.910 |
| CD52 | LY6K | ENSP00000363330 | ENSP00000292430 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth; LY6/PLAUR domain containing | 0.900 |
| CD52 | MSLN | ENSP00000363330 | ENSP00000372313 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | Mesothelin; Membrane-anchored forms may play a role in cellular adhesion | 0.902 |
| CD52 | NRN1 | ENSP00000363330 | ENSP00000480483 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | Neuritin; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells | 0.900 |
| CD52 | NRN1L | ENSP00000363330 | ENSP00000342411 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | Neuritin-like protein; Neuritin 1 like | 0.900 |
| CD52 | PRND | ENSP00000363330 | ENSP00000306900 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+); Belongs to the prion family | 0.900 |
| CPM | CD109 | ENSP00000448517 | ENSP00000287097 | Carboxypeptidase M; Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins; Belongs to the peptidase M14 family | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family | 0.901 |
| CPM | CD52 | ENSP00000448517 | ENSP00000363330 | Carboxypeptidase M; Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins; Belongs to the peptidase M14 family | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules | 0.900 |
