| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADCK2 | FAM65C | ENSP00000072869 | ENSP00000332663 | Uncharacterized aarF domain-containing protein kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | Family with sequence similarity 65, member C | 0.442 |
| COX14 | FAM65C | ENSP00000446524 | ENSP00000332663 | Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1 | Family with sequence similarity 65, member C | 0.420 |
| DNAJC11 | FAM65C | ENSP00000366800 | ENSP00000332663 | DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family | Family with sequence similarity 65, member C | 0.444 |
| ENSG00000279508 | FAM65C | ENSP00000485043 | ENSP00000332663 | annotation not available | Family with sequence similarity 65, member C | 0.669 |
| FAM65C | ADCK2 | ENSP00000332663 | ENSP00000072869 | Family with sequence similarity 65, member C | Uncharacterized aarF domain-containing protein kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | 0.442 |
| FAM65C | COX14 | ENSP00000332663 | ENSP00000446524 | Family with sequence similarity 65, member C | Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1 | 0.420 |
| FAM65C | DNAJC11 | ENSP00000332663 | ENSP00000366800 | Family with sequence similarity 65, member C | DnaJ homolog subfamily C member 11; Isoform 1- Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex; Belongs to the DNAJC11 family | 0.444 |
| FAM65C | ENSG00000279508 | ENSP00000332663 | ENSP00000485043 | Family with sequence similarity 65, member C | annotation not available | 0.669 |
| FAM65C | MECR | ENSP00000332663 | ENSP00000263702 | Family with sequence similarity 65, member C | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans- 2-hexadecenoyl-CoA (C16) | 0.424 |
| FAM65C | RHOC | ENSP00000332663 | ENSP00000285735 | Family with sequence similarity 65, member C | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells; Rho family GTPases | 0.560 |
| FAM65C | TMEM70 | ENSP00000332663 | ENSP00000312599 | Family with sequence similarity 65, member C | Transmembrane protein 70, mitochondrial; Involved in biogenesis of mitochondrial ATP synthase; Belongs to the TMEM70 family | 0.416 |
| MECR | FAM65C | ENSP00000263702 | ENSP00000332663 | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans- 2-hexadecenoyl-CoA (C16) | Family with sequence similarity 65, member C | 0.424 |
| RHOC | FAM65C | ENSP00000285735 | ENSP00000332663 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells; Rho family GTPases | Family with sequence similarity 65, member C | 0.560 |
| TMEM70 | FAM65C | ENSP00000312599 | ENSP00000332663 | Transmembrane protein 70, mitochondrial; Involved in biogenesis of mitochondrial ATP synthase; Belongs to the TMEM70 family | Family with sequence similarity 65, member C | 0.416 |
