• Version:
  • 11.0 [archived version]
STRINGSTRING
TMEM232 TMEM232 CHD3 CHD3 PRPF4 PRPF4 PRPF3 PRPF3 ZGPAT ZGPAT C20orf195 C20orf195 ARFRP1 ARFRP1 LIME1 LIME1 GMEB2 GMEB2 RTEL1 RTEL1 SLC2A4RG SLC2A4RG
"ZGPAT" - Zinc finger CCCH-type with G patch domain-containing protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZGPATZinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5’- GGAG[GA]A[GA]A-3’ consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis; G-patch domain containing (531 aa)    
Predicted Functional Partners:
PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein (683 aa)
     
 
  0.855
CHD3
Chromodomain-helicase-DNA-binding protein 3; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity; Belongs to the SNF2/RAD54 helicase family (2059 aa)
     
 
  0.761
ARFRP1
ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver; ARF GTPase family (201 aa)
     
   
  0.724
SLC2A4RG
SLC2A4 regulator; Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5’-GCCGGCG-3’ (387 aa)
     
   
  0.692
PRPF4
U4/U6 small nuclear ribonucleoprotein Prp4; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein (522 aa)
       
      0.687
GMEB2
Glucocorticoid modulatory element-binding protein 2; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses (530 aa)
     
   
  0.685
TMEM232
Transmembrane protein 232 (657 aa)
           
  0.670
RTEL1
Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1300 aa)
     
   
  0.624
LIME1
Lck-interacting transmembrane adapter 1; Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules (295 aa)
     
   
  0.623
C20orf195
Fibronectin type III domain-containing protein 11; Chromosome 20 open reading frame 195 (318 aa)
           
  0.615
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]