node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DAZAP1 | TSNARE1 | ENSP00000233078 | ENSP00000303437 | DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis | t-SNARE domain containing 1 | 0.420 |
DAZAP1 | ZNF789 | ENSP00000233078 | ENSP00000331927 | DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis | Zinc finger protein 789; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.547 |
LUC7L3 | RBM25 | ENSP00000425092 | ENSP00000261973 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing; Belongs to the Luc7 family | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5’-splice site (5’-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5’-ss usage through the 5’-CGGGCA-3’ RNA sequence. Its association with LUC7 [...] | 0.975 |
LUC7L3 | ZNF207 | ENSP00000425092 | ENSP00000378165 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing; Belongs to the Luc7 family | BUB3-interacting and GLEBS motif-containing protein ZNF207; Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetoc [...] | 0.482 |
LUC7L3 | ZNF789 | ENSP00000425092 | ENSP00000331927 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing; Belongs to the Luc7 family | Zinc finger protein 789; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.440 |
MTRNR2L8 | MTRNR2L9 | ENSP00000439666 | ENSP00000474840 | MT-RNR2 like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | Humanin-like 9; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | 0.669 |
MTRNR2L8 | TMEM41B | ENSP00000439666 | ENSP00000433126 | MT-RNR2 like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | Transmembrane protein 41B; Required for normal motor neuron development | 0.448 |
MTRNR2L8 | TSNARE1 | ENSP00000439666 | ENSP00000303437 | MT-RNR2 like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | t-SNARE domain containing 1 | 0.447 |
MTRNR2L8 | ZNF789 | ENSP00000439666 | ENSP00000331927 | MT-RNR2 like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | Zinc finger protein 789; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.473 |
MTRNR2L9 | MTRNR2L8 | ENSP00000474840 | ENSP00000439666 | Humanin-like 9; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | MT-RNR2 like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | 0.669 |
MTRNR2L9 | TMEM41B | ENSP00000474840 | ENSP00000433126 | Humanin-like 9; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | Transmembrane protein 41B; Required for normal motor neuron development | 0.400 |
MTRNR2L9 | TSNARE1 | ENSP00000474840 | ENSP00000303437 | Humanin-like 9; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | t-SNARE domain containing 1 | 0.400 |
MTRNR2L9 | ZNF789 | ENSP00000474840 | ENSP00000331927 | Humanin-like 9; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | Zinc finger protein 789; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.420 |
PHF19 | ZNF789 | ENSP00000483946 | ENSP00000331927 | PHD finger protein 19; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells- acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem c [...] | Zinc finger protein 789; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.481 |
RBM25 | LUC7L3 | ENSP00000261973 | ENSP00000425092 | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5’-splice site (5’-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5’-ss usage through the 5’-CGGGCA-3’ RNA sequence. Its association with LUC7 [...] | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing; Belongs to the Luc7 family | 0.975 |
RBM25 | ZNF789 | ENSP00000261973 | ENSP00000331927 | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5’-splice site (5’-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5’-ss usage through the 5’-CGGGCA-3’ RNA sequence. Its association with LUC7 [...] | Zinc finger protein 789; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.426 |
RIN1 | ZNF789 | ENSP00000310406 | ENSP00000331927 | Ras and Rab interactor 1; Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis; VPS9 domain containing | Zinc finger protein 789; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.478 |
TMEM41B | MTRNR2L8 | ENSP00000433126 | ENSP00000439666 | Transmembrane protein 41B; Required for normal motor neuron development | MT-RNR2 like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | 0.448 |
TMEM41B | MTRNR2L9 | ENSP00000433126 | ENSP00000474840 | Transmembrane protein 41B; Required for normal motor neuron development | Humanin-like 9; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family | 0.400 |
TMEM41B | TSNARE1 | ENSP00000433126 | ENSP00000303437 | Transmembrane protein 41B; Required for normal motor neuron development | t-SNARE domain containing 1 | 0.508 |