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  • 11.0 [archived version]
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MTRNR2L9 MTRNR2L9 MTRNR2L8 MTRNR2L8 TMEM41B TMEM41B TSNARE1 TSNARE1 DAZAP1 DAZAP1 RBM25 RBM25 ZNF789 ZNF789 LUC7L3 LUC7L3 PHF19 PHF19 ZNF207 ZNF207 RIN1 RIN1
"ZNF789" - Zinc finger protein 789 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ZNF789Zinc finger protein 789; May be involved in transcriptional regulation; Zinc fingers C2H2-type (425 aa)    
Predicted Functional Partners:
TMEM41B
Transmembrane protein 41B; Required for normal motor neuron development (291 aa)
     
   
  0.593
TSNARE1
t-SNARE domain containing 1 (514 aa)
     
   
  0.593
DAZAP1
DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis (407 aa)
     
   
  0.547
PHF19
PHD finger protein 19; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells- acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem c [...] (599 aa)
           
  0.481
RIN1
Ras and Rab interactor 1; Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis; VPS9 domain containing (783 aa)
           
  0.478
MTRNR2L8
MT-RNR2 like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family (24 aa)
           
  0.473
ZNF207
BUB3-interacting and GLEBS motif-containing protein ZNF207; Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetoc [...] (494 aa)
           
  0.453
LUC7L3
Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing; Belongs to the Luc7 family (432 aa)
           
  0.440
RBM25
RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5’-splice site (5’-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5’-ss usage through the 5’-CGGGCA-3’ RNA sequence. Its association with LUC7 [...] (843 aa)
     
 
  0.426
MTRNR2L9
Humanin-like 9; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family (24 aa)
           
  0.420
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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