| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD6 | RIPPLY3 | ENSP00000323280 | ENSP00000331734 | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lip [...] | Protein ripply3; Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity); Belongs to the ripply family | 0.540 |
| DSCR3 | DSCR4 | ENSP00000311399 | ENSP00000328676 | Down syndrome critical region gene 3; Belongs to the VPS26 family | Down syndrome critical region 4 | 0.726 |
| DSCR3 | KCNJ6 | ENSP00000311399 | ENSP00000477437 | Down syndrome critical region gene 3; Belongs to the VPS26 family | G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to [...] | 0.619 |
| DSCR3 | PIGP | ENSP00000311399 | ENSP00000420037 | Down syndrome critical region gene 3; Belongs to the VPS26 family | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis; Belongs to the PIGP family | 0.824 |
| DSCR3 | PRMT2 | ENSP00000311399 | ENSP00000380759 | Down syndrome critical region gene 3; Belongs to the VPS26 family | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation; Belongs to the class [...] | 0.638 |
| DSCR3 | PSMG1 | ENSP00000311399 | ENSP00000329915 | Down syndrome critical region gene 3; Belongs to the VPS26 family | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization | 0.671 |
| DSCR3 | RIPPLY3 | ENSP00000311399 | ENSP00000331734 | Down syndrome critical region gene 3; Belongs to the VPS26 family | Protein ripply3; Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity); Belongs to the ripply family | 0.646 |
| DSCR3 | SH3BGR | ENSP00000311399 | ENSP00000332513 | Down syndrome critical region gene 3; Belongs to the VPS26 family | SH3 domain-binding glutamic acid-rich protein; SH3 domain binding glutamate rich protein; Belongs to the SH3BGR family | 0.479 |
| DSCR4 | DSCR3 | ENSP00000328676 | ENSP00000311399 | Down syndrome critical region 4 | Down syndrome critical region gene 3; Belongs to the VPS26 family | 0.726 |
| DSCR4 | KCNJ6 | ENSP00000328676 | ENSP00000477437 | Down syndrome critical region 4 | G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to [...] | 0.559 |
| DSCR4 | PIGP | ENSP00000328676 | ENSP00000420037 | Down syndrome critical region 4 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis; Belongs to the PIGP family | 0.585 |
| DSCR4 | PSMG1 | ENSP00000328676 | ENSP00000329915 | Down syndrome critical region 4 | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization | 0.629 |
| DSCR4 | RIPPLY3 | ENSP00000328676 | ENSP00000331734 | Down syndrome critical region 4 | Protein ripply3; Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity); Belongs to the ripply family | 0.640 |
| DSCR4 | SH3BGR | ENSP00000328676 | ENSP00000332513 | Down syndrome critical region 4 | SH3 domain-binding glutamic acid-rich protein; SH3 domain binding glutamate rich protein; Belongs to the SH3BGR family | 0.473 |
| KCNJ6 | DSCR3 | ENSP00000477437 | ENSP00000311399 | G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to [...] | Down syndrome critical region gene 3; Belongs to the VPS26 family | 0.619 |
| KCNJ6 | DSCR4 | ENSP00000477437 | ENSP00000328676 | G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to [...] | Down syndrome critical region 4 | 0.559 |
| KCNJ6 | PRMT2 | ENSP00000477437 | ENSP00000380759 | G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to [...] | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation; Belongs to the class [...] | 0.684 |
| KCNJ6 | PSMG1 | ENSP00000477437 | ENSP00000329915 | G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to [...] | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization | 0.719 |
| KCNJ6 | RIPPLY3 | ENSP00000477437 | ENSP00000331734 | G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to [...] | Protein ripply3; Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity); Belongs to the ripply family | 0.645 |
| KCNJ6 | SH3BGR | ENSP00000477437 | ENSP00000332513 | G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to [...] | SH3 domain-binding glutamic acid-rich protein; SH3 domain binding glutamate rich protein; Belongs to the SH3BGR family | 0.674 |
