TMEM186 protein (human) - STRING database

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TMEM186

Transmembrane protein 186 (213 aa)

Predicted Functional Partners:

TMEM143

0.782

ECSIT

0.777

ARMC4

0.748

PHYHIPL

0.743

IQCE

0.729

C16orf72

0.705

GCHFR

0.683

NT5C3A

0.679

METTL22

0.670

ARHGAP20

0.663

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP20	TMEM186	ENSP00000260283	ENSP00000331640	Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state	Transmembrane protein 186	0.663
ARMC4	IQCE	ENSP00000306410	ENSP00000480715	Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing	IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling	0.660
ARMC4	NT5C3A	ENSP00000306410	ENSP00000484415	Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing	Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family	0.517
ARMC4	PHYHIPL	ENSP00000306410	ENSP00000362987	Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing	Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system; Fibronectin type III domain containing	0.589
ARMC4	TMEM143	ENSP00000306410	ENSP00000293261	Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing	Transmembrane protein 143	0.741
ARMC4	TMEM186	ENSP00000306410	ENSP00000331640	Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing	Transmembrane protein 186	0.748
C16orf72	METTL22	ENSP00000331720	ENSP00000371345	UPF0472 protein C16orf72; Chromosome 16 open reading frame 72	Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN; Belongs to the methyltransferase superfamily. METTL22 family	0.590
C16orf72	TMEM186	ENSP00000331720	ENSP00000331640	UPF0472 protein C16orf72; Chromosome 16 open reading frame 72	Transmembrane protein 186	0.705
ECSIT	TMEM186	ENSP00000270517	ENSP00000331640	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity); Belongs to the ECSIT family	Transmembrane protein 186	0.777
GCHFR	TMEM186	ENSP00000260447	ENSP00000331640	GTP cyclohydrolase 1 feedback regulatory protein; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine	Transmembrane protein 186	0.683
IQCE	ARMC4	ENSP00000480715	ENSP00000306410	IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling	Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing	0.660
IQCE	NT5C3A	ENSP00000480715	ENSP00000484415	IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling	Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family	0.538
IQCE	PHYHIPL	ENSP00000480715	ENSP00000362987	IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling	Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system; Fibronectin type III domain containing	0.695
IQCE	TMEM143	ENSP00000480715	ENSP00000293261	IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling	Transmembrane protein 143	0.670
IQCE	TMEM186	ENSP00000480715	ENSP00000331640	IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling	Transmembrane protein 186	0.729
METTL22	C16orf72	ENSP00000371345	ENSP00000331720	Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN; Belongs to the methyltransferase superfamily. METTL22 family	UPF0472 protein C16orf72; Chromosome 16 open reading frame 72	0.590
METTL22	TMEM186	ENSP00000371345	ENSP00000331640	Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN; Belongs to the methyltransferase superfamily. METTL22 family	Transmembrane protein 186	0.670
NT5C3A	ARMC4	ENSP00000484415	ENSP00000306410	Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family	Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing	0.517
NT5C3A	IQCE	ENSP00000484415	ENSP00000480715	Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family	IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling	0.538
NT5C3A	PHYHIPL	ENSP00000484415	ENSP00000362987	Cytosolic 5’-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5’-nucleotidase family	Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system; Fibronectin type III domain containing	0.605

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