node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf87 | CACNB2 | ENSP00000331581 | ENSP00000320025 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | 0.539 |
C11orf87 | DDX10 | ENSP00000331581 | ENSP00000314348 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | Probable ATP-dependent RNA helicase DDX10; Putative ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily | 0.426 |
C11orf87 | DRAM2 | ENSP00000331581 | ENSP00000286692 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | DNA damage-regulated autophagy modulator protein 2; Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1; Belongs to the DRAM/TMEM150 family | 0.653 |
C11orf87 | FAM126B | ENSP00000331581 | ENSP00000393667 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | Protein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane; Belongs to the FAM126 family | 0.422 |
C11orf87 | FAN1 | ENSP00000331581 | ENSP00000354497 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5’-3’ exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Pro [...] | 0.477 |
C11orf87 | TCF20 | ENSP00000331581 | ENSP00000352463 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | Transcription factor 20; Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator | 0.509 |
C11orf87 | TMEM115 | ENSP00000331581 | ENSP00000266025 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi; Rhomboid family | 0.473 |
C11orf87 | TMEM17 | ENSP00000331581 | ENSP00000335094 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | Transmembrane protein 17; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the TMEM17 family | 0.710 |
C11orf87 | TMEM87A | ENSP00000331581 | ENSP00000374484 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) | 0.742 |
C11orf87 | ZNF778 | ENSP00000331581 | ENSP00000405289 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | Zinc finger protein 778; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.420 |
CACNB2 | C11orf87 | ENSP00000320025 | ENSP00000331581 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | 0.539 |
DDX10 | C11orf87 | ENSP00000314348 | ENSP00000331581 | Probable ATP-dependent RNA helicase DDX10; Putative ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | 0.426 |
DRAM2 | C11orf87 | ENSP00000286692 | ENSP00000331581 | DNA damage-regulated autophagy modulator protein 2; Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1; Belongs to the DRAM/TMEM150 family | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | 0.653 |
DRAM2 | TMEM17 | ENSP00000286692 | ENSP00000335094 | DNA damage-regulated autophagy modulator protein 2; Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1; Belongs to the DRAM/TMEM150 family | Transmembrane protein 17; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the TMEM17 family | 0.465 |
DRAM2 | TMEM87A | ENSP00000286692 | ENSP00000374484 | DNA damage-regulated autophagy modulator protein 2; Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1; Belongs to the DRAM/TMEM150 family | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) | 0.547 |
FAM126B | C11orf87 | ENSP00000393667 | ENSP00000331581 | Protein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane; Belongs to the FAM126 family | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | 0.422 |
FAN1 | C11orf87 | ENSP00000354497 | ENSP00000331581 | Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5’-3’ exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Pro [...] | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | 0.477 |
TCF20 | C11orf87 | ENSP00000352463 | ENSP00000331581 | Transcription factor 20; Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | 0.509 |
TMEM115 | C11orf87 | ENSP00000266025 | ENSP00000331581 | Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi; Rhomboid family | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | 0.473 |
TMEM17 | C11orf87 | ENSP00000335094 | ENSP00000331581 | Transmembrane protein 17; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity); Belongs to the TMEM17 family | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 | 0.710 |