| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DBX2 | IRX3 | ENSP00000331470 | ENSP00000331608 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes | 0.647 |
| DBX2 | IRX6 | ENSP00000331470 | ENSP00000290552 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | Iroquois-class homeodomain protein IRX-6; TALE class homeoboxes and pseudogenes | 0.616 |
| DBX2 | ISL1 | ENSP00000331470 | ENSP00000230658 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5’-ATAATTAA-3’ in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | 0.519 |
| DBX2 | ISL2 | ENSP00000331470 | ENSP00000290759 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways; LIM class homeoboxes | 0.551 |
| DBX2 | LHX1 | ENSP00000331470 | ENSP00000477829 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis; LIM class homeoboxes | 0.478 |
| DBX2 | LHX5 | ENSP00000331470 | ENSP00000261731 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system; LIM class homeoboxes | 0.499 |
| DBX2 | OLIG2 | ENSP00000331470 | ENSP00000331040 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity); Basic helix-loop-helix proteins | 0.638 |
| DBX2 | PRDM12 | ENSP00000331470 | ENSP00000253008 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; PR/SET domain family | 0.513 |
| DBX2 | RANBP3L | ENSP00000331470 | ENSP00000421853 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | 0.521 |
| DBX2 | TIGD3 | ENSP00000331470 | ENSP00000308354 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | Tigger transposable element-derived protein 3; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.482 |
| IRX3 | DBX2 | ENSP00000331608 | ENSP00000331470 | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | 0.647 |
| IRX3 | ISL1 | ENSP00000331608 | ENSP00000230658 | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5’-ATAATTAA-3’ in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | 0.488 |
| IRX3 | ISL2 | ENSP00000331608 | ENSP00000290759 | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways; LIM class homeoboxes | 0.421 |
| IRX3 | LHX1 | ENSP00000331608 | ENSP00000477829 | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis; LIM class homeoboxes | 0.487 |
| IRX3 | OLIG2 | ENSP00000331608 | ENSP00000331040 | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity); TALE class homeoboxes and pseudogenes | Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity); Basic helix-loop-helix proteins | 0.739 |
| IRX6 | DBX2 | ENSP00000290552 | ENSP00000331470 | Iroquois-class homeodomain protein IRX-6; TALE class homeoboxes and pseudogenes | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes | 0.616 |
| IRX6 | ISL1 | ENSP00000290552 | ENSP00000230658 | Iroquois-class homeodomain protein IRX-6; TALE class homeoboxes and pseudogenes | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5’-ATAATTAA-3’ in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] | 0.560 |
| IRX6 | ISL2 | ENSP00000290552 | ENSP00000290759 | Iroquois-class homeodomain protein IRX-6; TALE class homeoboxes and pseudogenes | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways; LIM class homeoboxes | 0.498 |
| IRX6 | LHX1 | ENSP00000290552 | ENSP00000477829 | Iroquois-class homeodomain protein IRX-6; TALE class homeoboxes and pseudogenes | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis; LIM class homeoboxes | 0.540 |
| IRX6 | LHX5 | ENSP00000290552 | ENSP00000261731 | Iroquois-class homeodomain protein IRX-6; TALE class homeoboxes and pseudogenes | LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system; LIM class homeoboxes | 0.491 |
