GNB1L protein (human) - STRING database

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GNB1L

G protein subunit beta 1 like; WD repeat domain containing (327 aa)

Predicted Functional Partners:

GP1BB

0.714

PRODH2

0.714

SEPT5

0.713

DGCR8

0.700

POX2

0.690

UFD1L

0.682

STOML3

0.677

TBX1

0.668

CRKL

0.664

PIG6

0.663

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRKL	GNB1L	ENSP00000346300	ENSP00000331313	Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing	G protein subunit beta 1 like; WD repeat domain containing	0.664
CRKL	GP1BB	ENSP00000346300	ENSP00000383382	Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing	Platelet glycoprotein Ib beta chain; Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium; CD molecules	0.549
CRKL	SEPT5	ENSP00000346300	ENSP00000391311	Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing	Septin-5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family	0.566
CRKL	TBX1	ENSP00000346300	ENSP00000331791	Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing	T-box transcription factor TBX1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity); T-boxes	0.564
CRKL	UFD1L	ENSP00000346300	ENSP00000263202	Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing	Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derive [...]	0.470
DGCR8	GNB1L	ENSP00000263209	ENSP00000331313	Microprocessor complex subunit DGCR8; Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that [...]	G protein subunit beta 1 like; WD repeat domain containing	0.700
DGCR8	PIG6	ENSP00000263209	ENSP00000481127	Microprocessor complex subunit DGCR8; Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that [...]	Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate; Belongs to the proline oxidase family	0.423
DGCR8	POX2	ENSP00000263209	ENSP00000349577	Microprocessor complex subunit DGCR8; Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that [...]	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate; Belongs to the proline oxidase family	0.462
GNB1L	CRKL	ENSP00000331313	ENSP00000346300	G protein subunit beta 1 like; WD repeat domain containing	Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing	0.664
GNB1L	DGCR8	ENSP00000331313	ENSP00000263209	G protein subunit beta 1 like; WD repeat domain containing	Microprocessor complex subunit DGCR8; Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that [...]	0.700
GNB1L	GP1BB	ENSP00000331313	ENSP00000383382	G protein subunit beta 1 like; WD repeat domain containing	Platelet glycoprotein Ib beta chain; Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium; CD molecules	0.714
GNB1L	PIG6	ENSP00000331313	ENSP00000481127	G protein subunit beta 1 like; WD repeat domain containing	Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate; Belongs to the proline oxidase family	0.663
GNB1L	POX2	ENSP00000331313	ENSP00000349577	G protein subunit beta 1 like; WD repeat domain containing	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate; Belongs to the proline oxidase family	0.690
GNB1L	PRODH2	ENSP00000331313	ENSP00000301175	G protein subunit beta 1 like; WD repeat domain containing	Hydroxyproline dehydrogenase; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone- 10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp- trans-4-D-hydroxyproline and cis- 4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis	0.714
GNB1L	SEPT5	ENSP00000331313	ENSP00000391311	G protein subunit beta 1 like; WD repeat domain containing	Septin-5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family	0.713
GNB1L	STOML3	ENSP00000331313	ENSP00000368952	G protein subunit beta 1 like; WD repeat domain containing	Stomatin-like protein 3; Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations	0.677
GNB1L	TBX1	ENSP00000331313	ENSP00000331791	G protein subunit beta 1 like; WD repeat domain containing	T-box transcription factor TBX1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity); T-boxes	0.668
GNB1L	UFD1L	ENSP00000331313	ENSP00000263202	G protein subunit beta 1 like; WD repeat domain containing	Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derive [...]	0.682
GP1BB	CRKL	ENSP00000383382	ENSP00000346300	Platelet glycoprotein Ib beta chain; Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium; CD molecules	Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing	0.549
GP1BB	GNB1L	ENSP00000383382	ENSP00000331313	Platelet glycoprotein Ib beta chain; Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium; CD molecules	G protein subunit beta 1 like; WD repeat domain containing	0.714

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