node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF16 | LMNTD2 | ENSP00000367629 | ENSP00000331167 | Rho guanine nucleotide exchange factor 16; Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6; Pleckstrin homology domain containing | Lamin tail domain containing 2 | 0.403 |
C11orf88 | COPG2 | ENSP00000333845 | ENSP00000402346 | UPF0722 protein C11orf88; Chromosome 11 open reading frame 88 | Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] | 0.511 |
C11orf88 | LMNTD2 | ENSP00000333845 | ENSP00000331167 | UPF0722 protein C11orf88; Chromosome 11 open reading frame 88 | Lamin tail domain containing 2 | 0.709 |
C11orf88 | PRR33 | ENSP00000333845 | ENSP00000375311 | UPF0722 protein C11orf88; Chromosome 11 open reading frame 88 | Proline-rich protein 33; Proline rich 33 | 0.709 |
C11orf88 | RP1L1 | ENSP00000333845 | ENSP00000371923 | UPF0722 protein C11orf88; Chromosome 11 open reading frame 88 | Retinitis pigmentosa 1-like 1 protein; Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity); Doublecortin superfamily | 0.568 |
C11orf88 | TRPC4AP | ENSP00000333845 | ENSP00000252015 | UPF0722 protein C11orf88; Chromosome 11 open reading frame 88 | Short transient receptor potential channel 4-associated protein; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1; Armadill [...] | 0.527 |
CLEC2D | LMNTD2 | ENSP00000261340 | ENSP00000331167 | C-type lectin domain family 2 member D; Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans; C-type lectin domain containing | Lamin tail domain containing 2 | 0.424 |
COPG2 | C11orf88 | ENSP00000402346 | ENSP00000333845 | Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] | UPF0722 protein C11orf88; Chromosome 11 open reading frame 88 | 0.511 |
COPG2 | LMNTD2 | ENSP00000402346 | ENSP00000331167 | Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] | Lamin tail domain containing 2 | 0.408 |
COPG2 | PRR33 | ENSP00000402346 | ENSP00000375311 | Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] | Proline-rich protein 33; Proline rich 33 | 0.426 |
LMNTD2 | ARHGEF16 | ENSP00000331167 | ENSP00000367629 | Lamin tail domain containing 2 | Rho guanine nucleotide exchange factor 16; Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6; Pleckstrin homology domain containing | 0.403 |
LMNTD2 | C11orf88 | ENSP00000331167 | ENSP00000333845 | Lamin tail domain containing 2 | UPF0722 protein C11orf88; Chromosome 11 open reading frame 88 | 0.709 |
LMNTD2 | CLEC2D | ENSP00000331167 | ENSP00000261340 | Lamin tail domain containing 2 | C-type lectin domain family 2 member D; Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans; C-type lectin domain containing | 0.424 |
LMNTD2 | COPG2 | ENSP00000331167 | ENSP00000402346 | Lamin tail domain containing 2 | Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] | 0.408 |
LMNTD2 | PPP1R16A | ENSP00000331167 | ENSP00000292539 | Lamin tail domain containing 2 | Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates; Ankyrin repeat domain containing | 0.568 |
LMNTD2 | PRR33 | ENSP00000331167 | ENSP00000375311 | Lamin tail domain containing 2 | Proline-rich protein 33; Proline rich 33 | 0.652 |
LMNTD2 | RP1L1 | ENSP00000331167 | ENSP00000371923 | Lamin tail domain containing 2 | Retinitis pigmentosa 1-like 1 protein; Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity); Doublecortin superfamily | 0.494 |
LMNTD2 | SNX22 | ENSP00000331167 | ENSP00000323435 | Lamin tail domain containing 2 | Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the sorting nexin family | 0.566 |
LMNTD2 | TRPC4AP | ENSP00000331167 | ENSP00000252015 | Lamin tail domain containing 2 | Short transient receptor potential channel 4-associated protein; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1; Armadill [...] | 0.420 |
LMNTD2 | ZNF552 | ENSP00000331167 | ENSP00000375582 | Lamin tail domain containing 2 | Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.407 |