LMNTD2 protein (human) - STRING database

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LMNTD2

Lamin tail domain containing 2 (634 aa)

Predicted Functional Partners:

C11orf88

0.709

PRR33

0.652

PPP1R16A

0.568

SNX22

0.566

RP1L1

0.494

CLEC2D

0.424

TRPC4AP

0.420

COPG2

0.408

ZNF552

0.407

ARHGEF16

0.403

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF16	LMNTD2	ENSP00000367629	ENSP00000331167	Rho guanine nucleotide exchange factor 16; Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6; Pleckstrin homology domain containing	Lamin tail domain containing 2	0.403
C11orf88	COPG2	ENSP00000333845	ENSP00000402346	UPF0722 protein C11orf88; Chromosome 11 open reading frame 88	Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...]	0.511
C11orf88	LMNTD2	ENSP00000333845	ENSP00000331167	UPF0722 protein C11orf88; Chromosome 11 open reading frame 88	Lamin tail domain containing 2	0.709
C11orf88	PRR33	ENSP00000333845	ENSP00000375311	UPF0722 protein C11orf88; Chromosome 11 open reading frame 88	Proline-rich protein 33; Proline rich 33	0.709
C11orf88	RP1L1	ENSP00000333845	ENSP00000371923	UPF0722 protein C11orf88; Chromosome 11 open reading frame 88	Retinitis pigmentosa 1-like 1 protein; Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity); Doublecortin superfamily	0.568
C11orf88	TRPC4AP	ENSP00000333845	ENSP00000252015	UPF0722 protein C11orf88; Chromosome 11 open reading frame 88	Short transient receptor potential channel 4-associated protein; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1; Armadill [...]	0.527
CLEC2D	LMNTD2	ENSP00000261340	ENSP00000331167	C-type lectin domain family 2 member D; Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans; C-type lectin domain containing	Lamin tail domain containing 2	0.424
COPG2	C11orf88	ENSP00000402346	ENSP00000333845	Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...]	UPF0722 protein C11orf88; Chromosome 11 open reading frame 88	0.511
COPG2	LMNTD2	ENSP00000402346	ENSP00000331167	Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...]	Lamin tail domain containing 2	0.408
COPG2	PRR33	ENSP00000402346	ENSP00000375311	Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...]	Proline-rich protein 33; Proline rich 33	0.426
LMNTD2	ARHGEF16	ENSP00000331167	ENSP00000367629	Lamin tail domain containing 2	Rho guanine nucleotide exchange factor 16; Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6; Pleckstrin homology domain containing	0.403
LMNTD2	C11orf88	ENSP00000331167	ENSP00000333845	Lamin tail domain containing 2	UPF0722 protein C11orf88; Chromosome 11 open reading frame 88	0.709
LMNTD2	CLEC2D	ENSP00000331167	ENSP00000261340	Lamin tail domain containing 2	C-type lectin domain family 2 member D; Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans; C-type lectin domain containing	0.424
LMNTD2	COPG2	ENSP00000331167	ENSP00000402346	Lamin tail domain containing 2	Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...]	0.408
LMNTD2	PPP1R16A	ENSP00000331167	ENSP00000292539	Lamin tail domain containing 2	Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates; Ankyrin repeat domain containing	0.568
LMNTD2	PRR33	ENSP00000331167	ENSP00000375311	Lamin tail domain containing 2	Proline-rich protein 33; Proline rich 33	0.652
LMNTD2	RP1L1	ENSP00000331167	ENSP00000371923	Lamin tail domain containing 2	Retinitis pigmentosa 1-like 1 protein; Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity); Doublecortin superfamily	0.494
LMNTD2	SNX22	ENSP00000331167	ENSP00000323435	Lamin tail domain containing 2	Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the sorting nexin family	0.566
LMNTD2	TRPC4AP	ENSP00000331167	ENSP00000252015	Lamin tail domain containing 2	Short transient receptor potential channel 4-associated protein; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1; Armadill [...]	0.420
LMNTD2	ZNF552	ENSP00000331167	ENSP00000375582	Lamin tail domain containing 2	Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.407

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