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  • 11.0 [archived version]
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LRRC18 LRRC18 PCYT2 PCYT2 COPS3 COPS3 MYADML2 MYADML2 TMEM170B TMEM170B ADAP1 ADAP1 VSTM4 VSTM4 LMF1 LMF1 LYRM4 LYRM4 C10orf71 C10orf71 GPRC5D GPRC5D
"VSTM4" - V-set and transmembrane domain-containing protein 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
VSTM4V-set and transmembrane domain-containing protein 4; Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors; V-set domain containing (320 aa)    
Predicted Functional Partners:
TMEM170B
Transmembrane protein 170B (132 aa)
           
  0.802
LYRM4
LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; LYR motif containing (96 aa)
           
  0.714
LRRC18
Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation (261 aa)
       
 
  0.661
MYADML2
Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2 (307 aa)
           
  0.626
COPS3
COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-d [...] (423 aa)
           
  0.626
LMF1
Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL (567 aa)
           
  0.626
ADAP1
Arf-GAP with dual PH domain-containing protein 1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4); ArfGAPs (385 aa)
           
  0.625
PCYT2
Ethanolamine-phosphate cytidylyltransferase; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine (407 aa)
           
  0.621
C10orf71
Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 (1435 aa)
           
  0.586
GPRC5D
G protein-coupled receptor class C group 5 member D (345 aa)
           
  0.543
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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