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STRINGSTRING
OPCML OPCML CNTN5 CNTN5 CNTN4 CNTN4 LY6H LY6H MDGA1 MDGA1 NRN1 NRN1 RTN4RL1 RTN4RL1 CNTN3 CNTN3 NTNG2 NTNG2 NTNG1 NTNG1 RTN4RL2 RTN4RL2
"RTN4RL1" - Reticulon-4 receptor-like 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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RTN4RL1Reticulon-4 receptor-like 1; Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a [...] (441 aa)    
Predicted Functional Partners:
NTNG1
Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins (539 aa)
      
  0.919
CNTN3
Contactin-3; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity); Belongs to the immunoglobulin superfamily. Contactin family (1028 aa)
      
  0.915
CNTN5
Contactin-5; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity); Fibronectin type III domain containing (1100 aa)
      
    0.914
CNTN4
Contactin-4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis; Fibronectin type III domain containing (1026 aa)
      
  0.912
RTN4RL2
Reticulon-4 receptor-like 2; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, pl [...] (420 aa)
      
 
0.910
NTNG2
Netrin-G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Netrins (530 aa)
      
  0.910
NRN1
Neuritin; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells (168 aa)
      
 
  0.909
OPCML
Opioid-binding protein/cell adhesion molecule; Binds opioids in the presence of acidic lipids; probably involved in cell contact; Belongs to the immunoglobulin superfamily. IgLON family (345 aa)
      
  0.908
MDGA1
MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2; I-set domain containing (955 aa)
      
 
  0.907
LY6H
Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3-beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons; LY6/PLAUR domain containing (161 aa)
      
 
    0.907
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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