| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAMTS7 | HHIPL1 | ENSP00000373472 | ENSP00000330601 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP; ADAM metallopeptidases with thrombospondin type 1 motif | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | 0.578 |
| ADAMTS7 | KIAA1462 | ENSP00000373472 | ENSP00000364526 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP; ADAM metallopeptidases with thrombospondin type 1 motif | Junctional protein associated with coronary artery disease; KIAA1462 | 0.541 |
| ADAMTS7 | MRPS6 | ENSP00000373472 | ENSP00000382250 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP; ADAM metallopeptidases with thrombospondin type 1 motif | Mitochondrial ribosomal protein S6 | 0.412 |
| ADAMTS7 | UBE2Z | ENSP00000373472 | ENSP00000354201 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP; ADAM metallopeptidases with thrombospondin type 1 motif | Ubiquitin-conjugating enzyme E2 Z; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation; Ubiquitin conjugating enzymes E2 | 0.440 |
| ADAMTS7 | WDR12 | ENSP00000373472 | ENSP00000261015 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP; ADAM metallopeptidases with thrombospondin type 1 motif | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; WD repeat domain containing | 0.412 |
| BDKRB1 | HHIPL1 | ENSP00000216629 | ENSP00000330601 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | 0.686 |
| BIRC6 | HHIPL1 | ENSP00000393596 | ENSP00000330601 | Baculoviral IAP repeat-containing protein 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also [...] | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | 0.633 |
| CNNM2 | HHIPL1 | ENSP00000358894 | ENSP00000330601 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | 0.573 |
| CNNM2 | KIAA1462 | ENSP00000358894 | ENSP00000364526 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | Junctional protein associated with coronary artery disease; KIAA1462 | 0.456 |
| CNNM2 | MRPS6 | ENSP00000358894 | ENSP00000382250 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | Mitochondrial ribosomal protein S6 | 0.486 |
| CNNM2 | SMG6 | ENSP00000358894 | ENSP00000263073 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5’- (GTGTGG)(4)GTGT-3’ telomeric DNA, but not to a telomerase RNA template component (TER) | 0.463 |
| CNNM2 | UBE2Z | ENSP00000358894 | ENSP00000354201 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | Ubiquitin-conjugating enzyme E2 Z; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation; Ubiquitin conjugating enzymes E2 | 0.516 |
| CNNM2 | WDR12 | ENSP00000358894 | ENSP00000261015 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; WD repeat domain containing | 0.488 |
| HHIPL1 | ADAMTS7 | ENSP00000330601 | ENSP00000373472 | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP; ADAM metallopeptidases with thrombospondin type 1 motif | 0.578 |
| HHIPL1 | BDKRB1 | ENSP00000330601 | ENSP00000216629 | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | 0.686 |
| HHIPL1 | BIRC6 | ENSP00000330601 | ENSP00000393596 | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | Baculoviral IAP repeat-containing protein 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also [...] | 0.633 |
| HHIPL1 | CNNM2 | ENSP00000330601 | ENSP00000358894 | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | 0.573 |
| HHIPL1 | KIAA1462 | ENSP00000330601 | ENSP00000364526 | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | Junctional protein associated with coronary artery disease; KIAA1462 | 0.583 |
| HHIPL1 | MRPS6 | ENSP00000330601 | ENSP00000382250 | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | Mitochondrial ribosomal protein S6 | 0.560 |
| HHIPL1 | SMG6 | ENSP00000330601 | ENSP00000263073 | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5’- (GTGTGG)(4)GTGT-3’ telomeric DNA, but not to a telomerase RNA template component (TER) | 0.545 |
