| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1QL1 | C1QTNF8 | ENSP00000253407 | ENSP00000330426 | C1q-related factor; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | 0.432 |
| C1QTNF8 | C1QL1 | ENSP00000330426 | ENSP00000253407 | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | C1q-related factor; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related | 0.432 |
| C1QTNF8 | FAM132A | ENSP00000330426 | ENSP00000329137 | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue | 0.438 |
| C1QTNF8 | RLN1 | ENSP00000330426 | ENSP00000223862 | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family | 0.475 |
| C1QTNF8 | RLN2 | ENSP00000330426 | ENSP00000371040 | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | Prorelaxin H2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Endogenous ligands | 0.420 |
| C1QTNF8 | RXFP1 | ENSP00000330426 | ENSP00000405841 | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | 0.728 |
| C1QTNF8 | RXFP2 | ENSP00000330426 | ENSP00000298386 | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) | 0.450 |
| C1QTNF8 | TMEM120A | ENSP00000330426 | ENSP00000473983 | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | Transmembrane protein 120A; Necessary for efficient adipogenesis; Belongs to the TMEM120 family | 0.442 |
| FAM132A | C1QTNF8 | ENSP00000329137 | ENSP00000330426 | Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | 0.438 |
| RLN1 | C1QTNF8 | ENSP00000223862 | ENSP00000330426 | Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | 0.475 |
| RLN1 | RLN2 | ENSP00000223862 | ENSP00000371040 | Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family | Prorelaxin H2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Endogenous ligands | 0.845 |
| RLN1 | RXFP1 | ENSP00000223862 | ENSP00000405841 | Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | 0.977 |
| RLN1 | RXFP2 | ENSP00000223862 | ENSP00000298386 | Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) | 0.952 |
| RLN2 | C1QTNF8 | ENSP00000371040 | ENSP00000330426 | Prorelaxin H2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Endogenous ligands | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | 0.420 |
| RLN2 | RLN1 | ENSP00000371040 | ENSP00000223862 | Prorelaxin H2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Endogenous ligands | Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family | 0.845 |
| RLN2 | RXFP1 | ENSP00000371040 | ENSP00000405841 | Prorelaxin H2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Endogenous ligands | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | 0.992 |
| RLN2 | RXFP2 | ENSP00000371040 | ENSP00000298386 | Prorelaxin H2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Endogenous ligands | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) | 0.980 |
| RXFP1 | C1QTNF8 | ENSP00000405841 | ENSP00000330426 | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 | 0.728 |
| RXFP1 | RLN1 | ENSP00000405841 | ENSP00000223862 | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Belongs to the insulin family | 0.977 |
| RXFP1 | RLN2 | ENSP00000405841 | ENSP00000371040 | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | Prorelaxin H2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix; Endogenous ligands | 0.992 |
