PLEKHH1 protein (human) - STRING database

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Score

PLEKHH1

Pleckstrin homology, MyTH4 and FERM domain containing H1 (1364 aa)

Predicted Functional Partners:

APBB1IP

0.685

FAM83H

0.644

EFNB3

0.636

ZFYVE26

0.583

POLR3GL

0.575

ESF1

0.567

SLC16A9

0.563

TMEM217

0.561

C4orf29

0.559

PLEKHB1

0.553

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB1IP	PLEKHH1	ENSP00000365411	ENSP00000330278	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion; Belongs to the MRL family	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.685
C4orf29	ESF1	ENSP00000381937	ENSP00000202816	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	0.564
C4orf29	PLEKHB1	ENSP00000381937	ENSP00000346127	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing	0.437
C4orf29	PLEKHH1	ENSP00000381937	ENSP00000330278	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.559
C4orf29	POLR3GL	ENSP00000381937	ENSP00000358320	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	DNA-directed RNA polymerase III subunit RPC7-like; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC7 RNA polymerase subunit family	0.503
EFNB3	PLEKHH1	ENSP00000226091	ENSP00000330278	Ephrin-B3; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, an [...]	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.636
ESF1	C4orf29	ENSP00000202816	ENSP00000381937	ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	0.564
ESF1	PLEKHB1	ENSP00000202816	ENSP00000346127	ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing	0.516
ESF1	PLEKHH1	ENSP00000202816	ENSP00000330278	ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.567
ESF1	POLR3GL	ENSP00000202816	ENSP00000358320	ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	DNA-directed RNA polymerase III subunit RPC7-like; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC7 RNA polymerase subunit family	0.543
FAM83H	PLEKHH1	ENSP00000373565	ENSP00000330278	Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.644
PLEKHB1	C4orf29	ENSP00000346127	ENSP00000381937	Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	0.437
PLEKHB1	ESF1	ENSP00000346127	ENSP00000202816	Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing	ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	0.516
PLEKHB1	PLEKHH1	ENSP00000346127	ENSP00000330278	Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.553
PLEKHB1	POLR3GL	ENSP00000346127	ENSP00000358320	Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing	DNA-directed RNA polymerase III subunit RPC7-like; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC7 RNA polymerase subunit family	0.510
PLEKHH1	APBB1IP	ENSP00000330278	ENSP00000365411	Pleckstrin homology, MyTH4 and FERM domain containing H1	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion; Belongs to the MRL family	0.685
PLEKHH1	C4orf29	ENSP00000330278	ENSP00000381937	Pleckstrin homology, MyTH4 and FERM domain containing H1	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	0.559
PLEKHH1	EFNB3	ENSP00000330278	ENSP00000226091	Pleckstrin homology, MyTH4 and FERM domain containing H1	Ephrin-B3; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, an [...]	0.636
PLEKHH1	ESF1	ENSP00000330278	ENSP00000202816	Pleckstrin homology, MyTH4 and FERM domain containing H1	ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	0.567
PLEKHH1	FAM83H	ENSP00000330278	ENSP00000373565	Pleckstrin homology, MyTH4 and FERM domain containing H1	Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration	0.644

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