| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADA | ADSSL1 | ENSP00000361965 | ENSP00000333019 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ [...] | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.604 |
| ADA | NT5DC4 | ENSP00000361965 | ENSP00000330247 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ [...] | 5’-nucleotidase domain containing 4; Belongs to the 5’(3’)-deoxyribonucleotidase family | 0.482 |
| ADSSL1 | ADA | ENSP00000333019 | ENSP00000361965 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ [...] | 0.604 |
| ADSSL1 | HERPUD2 | ENSP00000333019 | ENSP00000379390 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway | 0.406 |
| ADSSL1 | NT5DC4 | ENSP00000333019 | ENSP00000330247 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 5’-nucleotidase domain containing 4; Belongs to the 5’(3’)-deoxyribonucleotidase family | 0.459 |
| APOL5 | CYB561A3 | ENSP00000249044 | ENSP00000389745 | Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity); Cytochrome b561 | 0.424 |
| APOL5 | HERPUD2 | ENSP00000249044 | ENSP00000379390 | Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway | 0.441 |
| APOL5 | NT5DC4 | ENSP00000249044 | ENSP00000330247 | Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 5’-nucleotidase domain containing 4; Belongs to the 5’(3’)-deoxyribonucleotidase family | 0.519 |
| BCAS3 | NT5DC4 | ENSP00000375067 | ENSP00000330247 | Breast carcinoma-amplified sequence 3; Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin; Belongs to the BCAS3 family | 5’-nucleotidase domain containing 4; Belongs to the 5’(3’)-deoxyribonucleotidase family | 0.511 |
| BCAS3 | PPAP2B | ENSP00000375067 | ENSP00000360296 | Breast carcinoma-amplified sequence 3; Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin; Belongs to the BCAS3 family | Phospholipid phosphatase 3; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions | 0.647 |
| CYB561A3 | APOL5 | ENSP00000389745 | ENSP00000249044 | Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity); Cytochrome b561 | Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 0.424 |
| CYB561A3 | HERPUD2 | ENSP00000389745 | ENSP00000379390 | Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity); Cytochrome b561 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway | 0.485 |
| CYB561A3 | NT5DC4 | ENSP00000389745 | ENSP00000330247 | Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity); Cytochrome b561 | 5’-nucleotidase domain containing 4; Belongs to the 5’(3’)-deoxyribonucleotidase family | 0.513 |
| ELP2 | HERPUD2 | ENSP00000414851 | ENSP00000379390 | Elongator complex protein 2; Regulates the ligand-dependent activation of STAT3; Belongs to the WD repeat ELP2 family | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway | 0.419 |
| ELP2 | NT5DC4 | ENSP00000414851 | ENSP00000330247 | Elongator complex protein 2; Regulates the ligand-dependent activation of STAT3; Belongs to the WD repeat ELP2 family | 5’-nucleotidase domain containing 4; Belongs to the 5’(3’)-deoxyribonucleotidase family | 0.466 |
| ERLIN1 | NT5DC4 | ENSP00000410964 | ENSP00000330247 | Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family | 5’-nucleotidase domain containing 4; Belongs to the 5’(3’)-deoxyribonucleotidase family | 0.543 |
| HERPUD2 | ADSSL1 | ENSP00000379390 | ENSP00000333019 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP | 0.406 |
| HERPUD2 | APOL5 | ENSP00000379390 | ENSP00000249044 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway | Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 0.441 |
| HERPUD2 | CYB561A3 | ENSP00000379390 | ENSP00000389745 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway | Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity); Cytochrome b561 | 0.485 |
| HERPUD2 | ELP2 | ENSP00000379390 | ENSP00000414851 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway | Elongator complex protein 2; Regulates the ligand-dependent activation of STAT3; Belongs to the WD repeat ELP2 family | 0.419 |
