node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC134 | CCDC34 | ENSP00000255784 | ENSP00000330240 | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family | Coiled-coil domain containing 34 | 0.667 |
CCDC134 | CCDC67 | ENSP00000255784 | ENSP00000298050 | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | 0.660 |
CCDC34 | CCDC134 | ENSP00000330240 | ENSP00000255784 | Coiled-coil domain containing 34 | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family | 0.667 |
CCDC34 | CCDC67 | ENSP00000330240 | ENSP00000298050 | Coiled-coil domain containing 34 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | 0.634 |
CCDC34 | FAM198B | ENSP00000330240 | ENSP00000377396 | Coiled-coil domain containing 34 | Protein FAM198B; Family with sequence similarity 198 member B; Belongs to the FAM198 family | 0.639 |
CCDC34 | FAM216A | ENSP00000330240 | ENSP00000366901 | Coiled-coil domain containing 34 | Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family | 0.713 |
CCDC34 | GINS2 | ENSP00000330240 | ENSP00000253462 | Coiled-coil domain containing 34 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | 0.558 |
CCDC34 | LGR4 | ENSP00000330240 | ENSP00000368516 | Coiled-coil domain containing 34 | Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] | 0.589 |
CCDC34 | LIN7C | ENSP00000330240 | ENSP00000278193 | Coiled-coil domain containing 34 | Protein lin-7 homolog C; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may funct [...] | 0.615 |
CCDC34 | RABL2A | ENSP00000330240 | ENSP00000376872 | Coiled-coil domain containing 34 | Rab-like protein 2A; Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail; RAB like GTPases | 0.519 |
CCDC34 | SLMAP | ENSP00000330240 | ENSP00000295951 | Coiled-coil domain containing 34 | Sarcolemmal membrane-associated protein; May play a role during myoblast fusion; STRIPAK complex | 0.544 |
CCDC34 | UBE2T | ENSP00000330240 | ENSP00000356243 | Coiled-coil domain containing 34 | Ubiquitin-conjugating enzyme E2 T; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using a [...] | 0.544 |
CCDC67 | CCDC134 | ENSP00000298050 | ENSP00000255784 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family | 0.660 |
CCDC67 | CCDC34 | ENSP00000298050 | ENSP00000330240 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity); Belongs to the CEP63 family | Coiled-coil domain containing 34 | 0.634 |
FAM198B | CCDC34 | ENSP00000377396 | ENSP00000330240 | Protein FAM198B; Family with sequence similarity 198 member B; Belongs to the FAM198 family | Coiled-coil domain containing 34 | 0.639 |
FAM198B | SLMAP | ENSP00000377396 | ENSP00000295951 | Protein FAM198B; Family with sequence similarity 198 member B; Belongs to the FAM198 family | Sarcolemmal membrane-associated protein; May play a role during myoblast fusion; STRIPAK complex | 0.431 |
FAM216A | CCDC34 | ENSP00000366901 | ENSP00000330240 | Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family | Coiled-coil domain containing 34 | 0.713 |
GINS2 | CCDC34 | ENSP00000253462 | ENSP00000330240 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | Coiled-coil domain containing 34 | 0.558 |
GINS2 | UBE2T | ENSP00000253462 | ENSP00000356243 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | Ubiquitin-conjugating enzyme E2 T; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using a [...] | 0.715 |
LGR4 | CCDC34 | ENSP00000368516 | ENSP00000330240 | Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] | Coiled-coil domain containing 34 | 0.589 |