• Version:
  • 11.0 [archived version]
STRINGSTRING
KRT18 KRT18 KRT32 KRT32 KRT16 KRT16 KRT27 KRT27 KRT25 KRT25 KRT76 KRT76 KRT14 KRT14 KRT37 KRT37 KRT24 KRT24 KRT10 KRT10 KRT38 KRT38
"KRT76" - Keratin, type II cytoskeletal 2 oral in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT76Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification; Keratins, type II (638 aa)    
Predicted Functional Partners:
KRT14
Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro (472 aa)
     
0.932
KRT38
Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family (456 aa)
     
0.931
KRT18
Keratin, type I cytoskeletal 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection; Keratins, type I (430 aa)
     
 
0.930
KRT25
Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (450 aa)
     
0.930
KRT16
Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance (473 aa)
     
0.929
KRT32
Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family (448 aa)
     
0.928
KRT27
Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (459 aa)
     
0.927
KRT37
Keratin, type I cuticular Ha7; Keratins, type I; Belongs to the intermediate filament family (449 aa)
     
0.926
KRT24
Keratin, type I cytoskeletal 24; Keratins, type I (525 aa)
     
0.925
KRT10
Keratin, type I cytoskeletal 10; Keratins, type I (584 aa)
     
0.924
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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