CCDC172 protein (human) - STRING database

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CCDC172

Coiled-coil domain containing 172 (258 aa)

Predicted Functional Partners:

TEKT5

0.626

TEKT2

0.626

NPM2

0.571

TEKT3

0.531

TEKT1

0.522

CCNF

0.473

TCL1B

0.422

TCL1A

0.403

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC172	CCNF	ENSP00000329860	ENSP00000380256	Coiled-coil domain containing 172	Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication; Belongs to the cyclin family. Cyclin AB subfamily	0.473
CCDC172	NPM2	ENSP00000329860	ENSP00000381032	Coiled-coil domain containing 172	Nucleoplasmin-2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization; Belongs to the nucleoplasmin family	0.571
CCDC172	TCL1A	ENSP00000329860	ENSP00000385036	Coiled-coil domain containing 172	T-cell leukemia/lymphoma protein 1A; Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival; Belongs to the TCL1 family	0.403
CCDC172	TCL1B	ENSP00000329860	ENSP00000343223	Coiled-coil domain containing 172	T-cell leukemia/lymphoma protein 1B; Enhances the phosphorylation and activation of AKT1 and AKT2; Belongs to the TCL1 family	0.422
CCDC172	TEKT1	ENSP00000329860	ENSP00000341346	Coiled-coil domain containing 172	Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family	0.522
CCDC172	TEKT2	ENSP00000329860	ENSP00000207457	Coiled-coil domain containing 172	Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Tektins	0.626
CCDC172	TEKT3	ENSP00000329860	ENSP00000379263	Coiled-coil domain containing 172	Tektin-3; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity); Tektins	0.531
CCDC172	TEKT5	ENSP00000329860	ENSP00000283025	Coiled-coil domain containing 172	Tektin-5; May be a structural component of the sperm flagellum; Tektins	0.626
CCNF	CCDC172	ENSP00000380256	ENSP00000329860	Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication; Belongs to the cyclin family. Cyclin AB subfamily	Coiled-coil domain containing 172	0.473
NPM2	CCDC172	ENSP00000381032	ENSP00000329860	Nucleoplasmin-2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization; Belongs to the nucleoplasmin family	Coiled-coil domain containing 172	0.571
TCL1A	CCDC172	ENSP00000385036	ENSP00000329860	T-cell leukemia/lymphoma protein 1A; Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival; Belongs to the TCL1 family	Coiled-coil domain containing 172	0.403
TCL1A	TCL1B	ENSP00000385036	ENSP00000343223	T-cell leukemia/lymphoma protein 1A; Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival; Belongs to the TCL1 family	T-cell leukemia/lymphoma protein 1B; Enhances the phosphorylation and activation of AKT1 and AKT2; Belongs to the TCL1 family	0.849
TCL1B	CCDC172	ENSP00000343223	ENSP00000329860	T-cell leukemia/lymphoma protein 1B; Enhances the phosphorylation and activation of AKT1 and AKT2; Belongs to the TCL1 family	Coiled-coil domain containing 172	0.422
TCL1B	TCL1A	ENSP00000343223	ENSP00000385036	T-cell leukemia/lymphoma protein 1B; Enhances the phosphorylation and activation of AKT1 and AKT2; Belongs to the TCL1 family	T-cell leukemia/lymphoma protein 1A; Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival; Belongs to the TCL1 family	0.849
TEKT1	CCDC172	ENSP00000341346	ENSP00000329860	Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family	Coiled-coil domain containing 172	0.522
TEKT2	CCDC172	ENSP00000207457	ENSP00000329860	Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Tektins	Coiled-coil domain containing 172	0.626
TEKT3	CCDC172	ENSP00000379263	ENSP00000329860	Tektin-3; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity); Tektins	Coiled-coil domain containing 172	0.531
TEKT5	CCDC172	ENSP00000283025	ENSP00000329860	Tektin-5; May be a structural component of the sperm flagellum; Tektins	Coiled-coil domain containing 172	0.626

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