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  • 11.0 [archived version]
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CAPZB CAPZB FMNL1 FMNL1 CAP1 CAP1 WDR90 WDR90 CAP2 CAP2 ACTL10 ACTL10 GGTLC1 GGTLC1 CDHR3 CDHR3 C5orf56 C5orf56 POM121L1P POM121L1P NECAB3 NECAB3
"ACTL10" - Actin-like protein 10 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
ACTL10Actin-like protein 10; Actin related proteins; Belongs to the actin family (245 aa)    
Predicted Functional Partners:
POM121L1P
annotation not available (429 aa)
           
  0.645
NECAB3
N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3; EF-hand domain containing (396 aa)
     
   
  0.607
C5orf56
Uncharacterized protein C5orf56; Chromosome 5 open reading frame 56 (126 aa)
           
  0.533
GGTLC1
Gamma-glutamyltransferase light chain 1; Gamma-glutamyltransferases (225 aa)
           
  0.518
CDHR3
Cadherin-related family member 3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (885 aa)
           
  0.470
CAPZB
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (301 aa)
     
 
  0.464
CAP1
Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family (475 aa)
     
 
  0.441
CAP2
Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family (477 aa)
     
 
  0.441
FMNL1
Formin-like protein 1; May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape; Armadillo-like helical domain containing (1100 aa)
       
 
  0.433
WDR90
WD repeat-containing protein 90; WD repeat domain containing (1748 aa)
     
 
  0.432
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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