| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD300C | GABARAPL1 | ENSP00000329507 | ENSP00000266458 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Belongs to the ATG8 family | 0.738 |
| CD300C | LILRA1 | ENSP00000329507 | ENSP00000251372 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | Leukocyte immunoglobulin-like receptor subfamily A member 1; May act as receptor for class I MHC antigens; Activating leukocyte immunoglobulin like receptors | 0.824 |
| CD300C | LILRA2 | ENSP00000329507 | ENSP00000251377 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | Leukocyte immunoglobulin-like receptor subfamily A member 2; Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind [...] | 0.824 |
| CD300C | LILRB1 | ENSP00000329507 | ENSP00000315997 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | Leukocyte immunoglobulin-like receptor subfamily B member 1; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediate [...] | 0.833 |
| CD300C | LILRB2 | ENSP00000329507 | ENSP00000375629 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | Leukocyte immunoglobulin-like receptor subfamily B member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions | 0.760 |
| CD300C | LILRB4 | ENSP00000329507 | ENSP00000375616 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | Leukocyte immunoglobulin-like receptor subfamily B member 4; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions; CD molecules | 0.766 |
| CD300C | MAP1LC3A | ENSP00000329507 | ENSP00000363970 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | Microtubule-associated proteins 1A/1B light chain 3A; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Autophagy related | 0.744 |
| CD300C | MAP1LC3B | ENSP00000329507 | ENSP00000268607 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | Microtubule-associated proteins 1A/1B light chain 3B; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellit [...] | 0.777 |
| CD300C | NBR1 | ENSP00000329507 | ENSP00000411250 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets; Zinc fingers ZZ-type | 0.796 |
| CD300C | TYROBP | ENSP00000329507 | ENSP00000262629 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.801 |
| GABARAPL1 | CD300C | ENSP00000266458 | ENSP00000329507 | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Belongs to the ATG8 family | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | 0.738 |
| GABARAPL1 | MAP1LC3A | ENSP00000266458 | ENSP00000363970 | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Belongs to the ATG8 family | Microtubule-associated proteins 1A/1B light chain 3A; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Autophagy related | 0.940 |
| GABARAPL1 | MAP1LC3B | ENSP00000266458 | ENSP00000268607 | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Belongs to the ATG8 family | Microtubule-associated proteins 1A/1B light chain 3B; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellit [...] | 0.919 |
| GABARAPL1 | NBR1 | ENSP00000266458 | ENSP00000411250 | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation; Belongs to the ATG8 family | Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets; Zinc fingers ZZ-type | 0.976 |
| LILRA1 | CD300C | ENSP00000251372 | ENSP00000329507 | Leukocyte immunoglobulin-like receptor subfamily A member 1; May act as receptor for class I MHC antigens; Activating leukocyte immunoglobulin like receptors | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | 0.824 |
| LILRA1 | LILRB2 | ENSP00000251372 | ENSP00000375629 | Leukocyte immunoglobulin-like receptor subfamily A member 1; May act as receptor for class I MHC antigens; Activating leukocyte immunoglobulin like receptors | Leukocyte immunoglobulin-like receptor subfamily B member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions | 0.533 |
| LILRA1 | TYROBP | ENSP00000251372 | ENSP00000262629 | Leukocyte immunoglobulin-like receptor subfamily A member 1; May act as receptor for class I MHC antigens; Activating leukocyte immunoglobulin like receptors | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.825 |
| LILRA2 | CD300C | ENSP00000251377 | ENSP00000329507 | Leukocyte immunoglobulin-like receptor subfamily A member 2; Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind [...] | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | 0.824 |
| LILRA2 | TYROBP | ENSP00000251377 | ENSP00000262629 | Leukocyte immunoglobulin-like receptor subfamily A member 2; Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans. Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling. Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind [...] | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.504 |
| LILRB1 | CD300C | ENSP00000315997 | ENSP00000329507 | Leukocyte immunoglobulin-like receptor subfamily B member 1; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediate [...] | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family | 0.833 |
