node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA5 | CCDC137 | ENSP00000376443 | ENSP00000329360 | ATP-binding cassette sub-family A member 5; May play a role in the processing of autolysosomes; Belongs to the ABC transporter superfamily. ABCA family | Coiled-coil domain containing 137 | 0.692 |
ABCA5 | TTYH2 | ENSP00000376443 | ENSP00000269346 | ATP-binding cassette sub-family A member 5; May play a role in the processing of autolysosomes; Belongs to the ABC transporter superfamily. ABCA family | Protein tweety homolog 2; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation; Belongs to the tweety family | 0.540 |
ABCA5 | UNK | ENSP00000376443 | ENSP00000464893 | ATP-binding cassette sub-family A member 5; May play a role in the processing of autolysosomes; Belongs to the ABC transporter superfamily. ABCA family | RING finger protein unkempt homolog; Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes; Zinc fingers CCCH-type | 0.433 |
BTBD17 | CCDC137 | ENSP00000364515 | ENSP00000329360 | BTB/POZ domain-containing protein 17; BTB domain containing 17 | Coiled-coil domain containing 137 | 0.607 |
BTBD17 | TTYH2 | ENSP00000364515 | ENSP00000269346 | BTB/POZ domain-containing protein 17; BTB domain containing 17 | Protein tweety homolog 2; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation; Belongs to the tweety family | 0.425 |
C1orf131 | CCDC137 | ENSP00000355609 | ENSP00000329360 | Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131 | Coiled-coil domain containing 137 | 0.734 |
CCDC137 | ABCA5 | ENSP00000329360 | ENSP00000376443 | Coiled-coil domain containing 137 | ATP-binding cassette sub-family A member 5; May play a role in the processing of autolysosomes; Belongs to the ABC transporter superfamily. ABCA family | 0.692 |
CCDC137 | BTBD17 | ENSP00000329360 | ENSP00000364515 | Coiled-coil domain containing 137 | BTB/POZ domain-containing protein 17; BTB domain containing 17 | 0.607 |
CCDC137 | C1orf131 | ENSP00000329360 | ENSP00000355609 | Coiled-coil domain containing 137 | Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131 | 0.734 |
CCDC137 | KCNJ14 | ENSP00000329360 | ENSP00000375756 | Coiled-coil domain containing 137 | ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] | 0.632 |
CCDC137 | KCNJ16 | ENSP00000329360 | ENSP00000465295 | Coiled-coil domain containing 137 | Inward rectifier potassium channel 16; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolater [...] | 0.628 |
CCDC137 | RPL8 | ENSP00000329360 | ENSP00000262584 | Coiled-coil domain containing 137 | 60S ribosomal protein L8; Component of the large ribosomal subunit | 0.652 |
CCDC137 | RRP8 | ENSP00000329360 | ENSP00000254605 | Coiled-coil domain containing 137 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell- upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ’Lys- 9’ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | 0.664 |
CCDC137 | TMEM69 | ENSP00000329360 | ENSP00000361095 | Coiled-coil domain containing 137 | Transmembrane protein 69 | 0.630 |
CCDC137 | TTYH2 | ENSP00000329360 | ENSP00000269346 | Coiled-coil domain containing 137 | Protein tweety homolog 2; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation; Belongs to the tweety family | 0.708 |
CCDC137 | UNK | ENSP00000329360 | ENSP00000464893 | Coiled-coil domain containing 137 | RING finger protein unkempt homolog; Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes; Zinc fingers CCCH-type | 0.730 |
KCNJ14 | CCDC137 | ENSP00000375756 | ENSP00000329360 | ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] | Coiled-coil domain containing 137 | 0.632 |
KCNJ14 | TTYH2 | ENSP00000375756 | ENSP00000269346 | ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] | Protein tweety homolog 2; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation; Belongs to the tweety family | 0.535 |
KCNJ16 | CCDC137 | ENSP00000465295 | ENSP00000329360 | Inward rectifier potassium channel 16; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolater [...] | Coiled-coil domain containing 137 | 0.628 |
KCNJ16 | TTYH2 | ENSP00000465295 | ENSP00000269346 | Inward rectifier potassium channel 16; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolater [...] | Protein tweety homolog 2; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation; Belongs to the tweety family | 0.489 |