node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEND1 | NXPH3 | ENSP00000328336 | ENSP00000329295 | Cell cycle exit and neuronal differentiation protein 1; Involved in neuronal differentiation; Belongs to the CEND1 family | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | 0.495 |
ECEL1 | NXPH3 | ENSP00000302051 | ENSP00000329295 | Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides; M13 metallopeptidases | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | 0.647 |
NCDN | NXPH3 | ENSP00000362340 | ENSP00000329295 | Neurochondrin; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth; Belongs to [...] | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | 0.494 |
NPS | NRXN1 | ENSP00000381105 | ENSP00000385142 | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | 0.506 |
NPS | NXPH3 | ENSP00000381105 | ENSP00000329295 | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | 0.715 |
NPS | RXFP1 | ENSP00000381105 | ENSP00000405841 | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | 0.910 |
NRXN1 | NPS | ENSP00000385142 | ENSP00000381105 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | 0.506 |
NRXN1 | NXPH3 | ENSP00000385142 | ENSP00000329295 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | 0.856 |
NXPE3 | NXPH3 | ENSP00000396421 | ENSP00000329295 | NXPE family member 3; Neurexophilin and PC-esterase domain family member 3 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | 0.538 |
NXPE4 | NXPH3 | ENSP00000364627 | ENSP00000329295 | NXPE family member 4; Neurexophilin and PC-esterase domain family member 4; Belongs to the NXPE family | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | 0.556 |
NXPH3 | CEND1 | ENSP00000329295 | ENSP00000328336 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | Cell cycle exit and neuronal differentiation protein 1; Involved in neuronal differentiation; Belongs to the CEND1 family | 0.495 |
NXPH3 | ECEL1 | ENSP00000329295 | ENSP00000302051 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides; M13 metallopeptidases | 0.647 |
NXPH3 | NCDN | ENSP00000329295 | ENSP00000362340 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | Neurochondrin; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth; Belongs to [...] | 0.494 |
NXPH3 | NPS | ENSP00000329295 | ENSP00000381105 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | 0.715 |
NXPH3 | NRXN1 | ENSP00000329295 | ENSP00000385142 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | 0.856 |
NXPH3 | NXPE3 | ENSP00000329295 | ENSP00000396421 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | NXPE family member 3; Neurexophilin and PC-esterase domain family member 3 | 0.538 |
NXPH3 | NXPE4 | ENSP00000329295 | ENSP00000364627 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | NXPE family member 4; Neurexophilin and PC-esterase domain family member 4; Belongs to the NXPE family | 0.556 |
NXPH3 | OR10J3 | ENSP00000329295 | ENSP00000331789 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | Olfactory receptor 10J3; Odorant receptor; Olfactory receptors, family 10 | 0.509 |
NXPH3 | RXFP1 | ENSP00000329295 | ENSP00000405841 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | 0.619 |
NXPH3 | TUBA1A | ENSP00000329295 | ENSP00000301071 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family | Tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins | 0.509 |