node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS3 | ASNA1 | ENSP00000286657 | ENSP00000466379 | A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens; ADAM metallopeptidases with thrombospondin type 1 motif | ATPase ASNA1; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.634 |
ADAMTS3 | SNN | ENSP00000286657 | ENSP00000329287 | A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens; ADAM metallopeptidases with thrombospondin type 1 motif | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | 0.646 |
ADAMTS3 | TMEM86A | ENSP00000286657 | ENSP00000280734 | A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens; ADAM metallopeptidases with thrombospondin type 1 motif | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A | 0.666 |
ADAMTS3 | VIPR1 | ENSP00000286657 | ENSP00000327246 | A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens; ADAM metallopeptidases with thrombospondin type 1 motif | Vasoactive intestinal polypeptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38; Vasoactive intestinal peptide receptor family | 0.626 |
ASNA1 | ADAMTS3 | ENSP00000466379 | ENSP00000286657 | ATPase ASNA1; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens; ADAM metallopeptidases with thrombospondin type 1 motif | 0.634 |
ASNA1 | SNN | ENSP00000466379 | ENSP00000329287 | ATPase ASNA1; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | 0.587 |
ASNA1 | TMEM86A | ENSP00000466379 | ENSP00000280734 | ATPase ASNA1; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A | 0.709 |
ASNA1 | VIPR1 | ENSP00000466379 | ENSP00000327246 | ATPase ASNA1; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Vasoactive intestinal polypeptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38; Vasoactive intestinal peptide receptor family | 0.636 |
FST | SNN | ENSP00000256759 | ENSP00000329287 | Follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | 0.785 |
HMCN2 | SNN | ENSP00000485357 | ENSP00000329287 | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | 0.564 |
SERPINA4 | SNN | ENSP00000450838 | ENSP00000329287 | Kallistatin; Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein; Belongs to the serpin family | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | 0.586 |
SNN | ADAMTS3 | ENSP00000329287 | ENSP00000286657 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens; ADAM metallopeptidases with thrombospondin type 1 motif | 0.646 |
SNN | ASNA1 | ENSP00000329287 | ENSP00000466379 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | ATPase ASNA1; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.587 |
SNN | FST | ENSP00000329287 | ENSP00000256759 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | Follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | 0.785 |
SNN | HMCN2 | ENSP00000329287 | ENSP00000485357 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | Hemicentin-2; Immunoglobulin like domain containing; Fibulins | 0.564 |
SNN | SERPINA4 | ENSP00000329287 | ENSP00000450838 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | Kallistatin; Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein; Belongs to the serpin family | 0.586 |
SNN | SPIN4 | ENSP00000329287 | ENSP00000334163 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | Spindlin-4; Exhibits H3K4me3-binding activity; Spindlin family | 0.733 |
SNN | TMEM86A | ENSP00000329287 | ENSP00000280734 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A | 0.599 |
SNN | TXNDC11 | ENSP00000329287 | ENSP00000283033 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | Thioredoxin domain-containing protein 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation | 0.681 |
SNN | VIPR1 | ENSP00000329287 | ENSP00000327246 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation | Vasoactive intestinal polypeptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38; Vasoactive intestinal peptide receptor family | 0.652 |