node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACADSB | FAM198A | ENSP00000357873 | ENSP00000407301 | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | 0.404 |
ACADSB | HEXDC | ENSP00000357873 | ENSP00000337854 | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent | Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family | 0.409 |
ACADSB | ZNF662 | ENSP00000357873 | ENSP00000329264 | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent | Zinc finger protein 662; Zinc fingers C2H2-type | 0.448 |
ARMC7 | ATP13A3 | ENSP00000245543 | ENSP00000416508 | Armadillo repeat containing 7 | Probable cation-transporting ATPase 13A3; ATPase orphan transporters | 0.430 |
ARMC7 | FAM198A | ENSP00000245543 | ENSP00000407301 | Armadillo repeat containing 7 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | 0.622 |
ARMC7 | HEXDC | ENSP00000245543 | ENSP00000337854 | Armadillo repeat containing 7 | Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family | 0.565 |
ARMC7 | IKBIP | ENSP00000245543 | ENSP00000299157 | Armadillo repeat containing 7 | IKBKB interacting protein | 0.440 |
ARMC7 | LSG1 | ENSP00000245543 | ENSP00000265245 | Armadillo repeat containing 7 | Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable) | 0.501 |
ARMC7 | TEN1 | ENSP00000245543 | ENSP00000380762 | Armadillo repeat containing 7 | CST complex subunit TEN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | 0.437 |
ARMC7 | ZNF662 | ENSP00000245543 | ENSP00000329264 | Armadillo repeat containing 7 | Zinc finger protein 662; Zinc fingers C2H2-type | 0.650 |
ATP13A3 | ARMC7 | ENSP00000416508 | ENSP00000245543 | Probable cation-transporting ATPase 13A3; ATPase orphan transporters | Armadillo repeat containing 7 | 0.430 |
ATP13A3 | FAM198A | ENSP00000416508 | ENSP00000407301 | Probable cation-transporting ATPase 13A3; ATPase orphan transporters | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | 0.457 |
ATP13A3 | ZNF662 | ENSP00000416508 | ENSP00000329264 | Probable cation-transporting ATPase 13A3; ATPase orphan transporters | Zinc finger protein 662; Zinc fingers C2H2-type | 0.492 |
FAM198A | ACADSB | ENSP00000407301 | ENSP00000357873 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent | 0.404 |
FAM198A | ARMC7 | ENSP00000407301 | ENSP00000245543 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Armadillo repeat containing 7 | 0.622 |
FAM198A | ATP13A3 | ENSP00000407301 | ENSP00000416508 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Probable cation-transporting ATPase 13A3; ATPase orphan transporters | 0.457 |
FAM198A | HEXDC | ENSP00000407301 | ENSP00000337854 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family | 0.580 |
FAM198A | IKBIP | ENSP00000407301 | ENSP00000299157 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | IKBKB interacting protein | 0.516 |
FAM198A | LSG1 | ENSP00000407301 | ENSP00000265245 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable) | 0.507 |
FAM198A | TEN1 | ENSP00000407301 | ENSP00000380762 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family | CST complex subunit TEN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | 0.474 |