| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DRD4 | GNG4 | ENSP00000176183 | ENSP00000375727 | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.912 |
| DRD4 | GPR37L1 | ENSP00000176183 | ENSP00000356251 | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | Prosaposin receptor GPR37L1; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; G protein-coupled receptors, Class A orphans | 0.931 |
| DRD4 | INSL5 | ENSP00000176183 | ENSP00000302724 | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family | 0.900 |
| DRD4 | NPY | ENSP00000176183 | ENSP00000384364 | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | Pro-neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family | 0.947 |
| DRD4 | RLN3 | ENSP00000176183 | ENSP00000397415 | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | Relaxin-3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family | 0.921 |
| DRD4 | RXFP3 | ENSP00000176183 | ENSP00000328708 | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation; Relaxin family peptide receptors | 0.944 |
| DRD4 | SST | ENSP00000176183 | ENSP00000287641 | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | Somatostatin; Somatostatin inhibits the release of somatotropin; Endogenous ligands | 0.945 |
| DRD4 | TAS2R13 | ENSP00000176183 | ENSP00000375095 | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | Taste receptor type 2 member 13; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5; Belongs to the G-protein coupled receptor T2R family | 0.903 |
| GNG4 | DRD4 | ENSP00000375727 | ENSP00000176183 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | 0.912 |
| GNG4 | GPR37L1 | ENSP00000375727 | ENSP00000356251 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Prosaposin receptor GPR37L1; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; G protein-coupled receptors, Class A orphans | 0.915 |
| GNG4 | INSL5 | ENSP00000375727 | ENSP00000302724 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family | 0.901 |
| GNG4 | NPY | ENSP00000375727 | ENSP00000384364 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Pro-neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family | 0.915 |
| GNG4 | RLN3 | ENSP00000375727 | ENSP00000397415 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Relaxin-3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family | 0.900 |
| GNG4 | RXFP1 | ENSP00000375727 | ENSP00000405841 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors | 0.900 |
| GNG4 | RXFP2 | ENSP00000375727 | ENSP00000298386 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) | 0.900 |
| GNG4 | RXFP3 | ENSP00000375727 | ENSP00000328708 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation; Relaxin family peptide receptors | 0.920 |
| GNG4 | SST | ENSP00000375727 | ENSP00000287641 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Somatostatin; Somatostatin inhibits the release of somatotropin; Endogenous ligands | 0.905 |
| GNG4 | TAS2R13 | ENSP00000375727 | ENSP00000375095 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | Taste receptor type 2 member 13; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5; Belongs to the G-protein coupled receptor T2R family | 0.900 |
| GPR37L1 | DRD4 | ENSP00000356251 | ENSP00000176183 | Prosaposin receptor GPR37L1; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; G protein-coupled receptors, Class A orphans | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family | 0.931 |
| GPR37L1 | GNG4 | ENSP00000356251 | ENSP00000375727 | Prosaposin receptor GPR37L1; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; G protein-coupled receptors, Class A orphans | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.915 |
