| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD46 | ZNF696 | ENSP00000429015 | ENSP00000328515 | Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.471 |
| BOLA3 | ZFYVE28 | ENSP00000331369 | ENSP00000290974 | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1; Belongs to the BolA/IbaG family | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Belongs to the lst-2 family | 0.571 |
| BOLA3 | ZNF696 | ENSP00000331369 | ENSP00000328515 | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1; Belongs to the BolA/IbaG family | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.433 |
| IPO8 | ZNF696 | ENSP00000256079 | ENSP00000328515 | Importin-8; Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the [...] | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.432 |
| PPP1R16A | ZNF696 | ENSP00000292539 | ENSP00000328515 | Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates; Ankyrin repeat domain containing | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.518 |
| PYCRL | ZNF696 | ENSP00000220966 | ENSP00000328515 | Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.511 |
| TOP1MT | ZNF696 | ENSP00000328835 | ENSP00000328515 | DNA topoisomerase I, mitochondrial; Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5’-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, [...] | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.446 |
| TRIM28 | ZNF696 | ENSP00000253024 | ENSP00000328515 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.917 |
| XKR9 | ZNF696 | ENSP00000386141 | ENSP00000328515 | XK-related protein 9; XK related family | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.581 |
| ZBTB25 | ZNF696 | ENSP00000476746 | ENSP00000328515 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.505 |
| ZFYVE28 | BOLA3 | ENSP00000290974 | ENSP00000331369 | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Belongs to the lst-2 family | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1; Belongs to the BolA/IbaG family | 0.571 |
| ZFYVE28 | ZNF696 | ENSP00000290974 | ENSP00000328515 | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Belongs to the lst-2 family | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.472 |
| ZNF696 | ANKRD46 | ENSP00000328515 | ENSP00000429015 | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing | 0.471 |
| ZNF696 | BOLA3 | ENSP00000328515 | ENSP00000331369 | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1; Belongs to the BolA/IbaG family | 0.433 |
| ZNF696 | IPO8 | ENSP00000328515 | ENSP00000256079 | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Importin-8; Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the [...] | 0.432 |
| ZNF696 | PPP1R16A | ENSP00000328515 | ENSP00000292539 | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates; Ankyrin repeat domain containing | 0.518 |
| ZNF696 | PYCRL | ENSP00000328515 | ENSP00000220966 | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline | 0.511 |
| ZNF696 | TOP1MT | ENSP00000328515 | ENSP00000328835 | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | DNA topoisomerase I, mitochondrial; Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5’-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, [...] | 0.446 |
| ZNF696 | TRIM28 | ENSP00000328515 | ENSP00000253024 | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.917 |
| ZNF696 | XKR9 | ENSP00000328515 | ENSP00000386141 | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | XK-related protein 9; XK related family | 0.581 |
