| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C4A | C4B | ENSP00000396688 | ENSP00000415941 | Complement C4-A; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens | Complement C4-B; Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens | 0.995 |
| C4A | VMO1 | ENSP00000396688 | ENSP00000328397 | Complement C4-A; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | 0.406 |
| C4B | C4A | ENSP00000415941 | ENSP00000396688 | Complement C4-B; Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens | Complement C4-A; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens | 0.995 |
| C4B | VMO1 | ENSP00000415941 | ENSP00000328397 | Complement C4-B; Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | 0.453 |
| C9orf131 | VMO1 | ENSP00000308279 | ENSP00000328397 | Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | 0.400 |
| EFCAB11 | VMO1 | ENSP00000326267 | ENSP00000328397 | EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | 0.420 |
| LYZ | VMO1 | ENSP00000261267 | ENSP00000328397 | Lysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents; Lysozymes, c-type | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | 0.579 |
| PTGR1 | VMO1 | ENSP00000385763 | ENSP00000328397 | Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | 0.424 |
| SHBG | VMO1 | ENSP00000369816 | ENSP00000328397 | Sex hormone-binding globulin; Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | 0.413 |
| SPEF1 | VMO1 | ENSP00000369080 | ENSP00000328397 | Sperm flagellar protein 1; Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule- associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity) | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | 0.403 |
| VMO1 | C4A | ENSP00000328397 | ENSP00000396688 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | Complement C4-A; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens | 0.406 |
| VMO1 | C4B | ENSP00000328397 | ENSP00000415941 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | Complement C4-B; Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens | 0.453 |
| VMO1 | C9orf131 | ENSP00000328397 | ENSP00000308279 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131 | 0.400 |
| VMO1 | EFCAB11 | ENSP00000328397 | ENSP00000326267 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11 | 0.420 |
| VMO1 | LYZ | ENSP00000328397 | ENSP00000261267 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | Lysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents; Lysozymes, c-type | 0.579 |
| VMO1 | PTGR1 | ENSP00000328397 | ENSP00000385763 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 | 0.424 |
| VMO1 | SHBG | ENSP00000328397 | ENSP00000369816 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | Sex hormone-binding globulin; Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration | 0.413 |
| VMO1 | SPEF1 | ENSP00000328397 | ENSP00000369080 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family | Sperm flagellar protein 1; Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule- associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity) | 0.403 |
