| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKAP2 | CDKL5 | ENSP00000404782 | ENSP00000369325 | A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity); A-kinase anchoring proteins | Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated | 0.452 |
| AKAP2 | PTTG1IP | ENSP00000404782 | ENSP00000328325 | A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity); A-kinase anchoring proteins | Pituitary tumor-transforming gene 1 protein-interacting protein; May facilitate PTTG1 nuclear translocation | 0.515 |
| CDKL5 | AKAP2 | ENSP00000369325 | ENSP00000404782 | Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated | A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity); A-kinase anchoring proteins | 0.452 |
| CDKL5 | ENSG00000157654 | ENSP00000369325 | ENSP00000363654 | Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated | A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity) | 0.455 |
| CDKL5 | PTTG1IP | ENSP00000369325 | ENSP00000328325 | Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated | Pituitary tumor-transforming gene 1 protein-interacting protein; May facilitate PTTG1 nuclear translocation | 0.661 |
| ENSG00000157654 | CDKL5 | ENSP00000363654 | ENSP00000369325 | A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity) | Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated | 0.455 |
| ENSG00000157654 | PTTG1IP | ENSP00000363654 | ENSP00000328325 | A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity) | Pituitary tumor-transforming gene 1 protein-interacting protein; May facilitate PTTG1 nuclear translocation | 0.517 |
| JAM2 | NDUFV3 | ENSP00000383376 | ENSP00000346196 | Junctional adhesion molecule B; May play a role in the processes of lymphocyte homing to secondary lymphoid organs; Belongs to the immunoglobulin superfamily | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I | 0.529 |
| JAM2 | PKNOX1 | ENSP00000383376 | ENSP00000291547 | Junctional adhesion molecule B; May play a role in the processes of lymphocyte homing to secondary lymphoid organs; Belongs to the immunoglobulin superfamily | Homeobox protein PKNOX1; TALE class homeoboxes and pseudogenes | 0.573 |
| JAM2 | PTTG1IP | ENSP00000383376 | ENSP00000328325 | Junctional adhesion molecule B; May play a role in the processes of lymphocyte homing to secondary lymphoid organs; Belongs to the immunoglobulin superfamily | Pituitary tumor-transforming gene 1 protein-interacting protein; May facilitate PTTG1 nuclear translocation | 0.626 |
| JAM2 | SYNJ1 | ENSP00000383376 | ENSP00000409667 | Junctional adhesion molecule B; May play a role in the processes of lymphocyte homing to secondary lymphoid organs; Belongs to the immunoglobulin superfamily | Synaptojanin-1; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity); Belongs to the synaptojanin family | 0.527 |
| JAM2 | U2AF1L4 | ENSP00000383376 | ENSP00000292879 | Junctional adhesion molecule B; May play a role in the processes of lymphocyte homing to secondary lymphoid organs; Belongs to the immunoglobulin superfamily | Splicing factor U2AF 35 kDa subunit-like protein; U2 small nuclear RNA auxiliary factor 1 like 4; RNA binding motif containing | 0.502 |
| JAM2 | WDR4 | ENSP00000383376 | ENSP00000381266 | Junctional adhesion molecule B; May play a role in the processes of lymphocyte homing to secondary lymphoid organs; Belongs to the immunoglobulin superfamily | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit; Belongs to the WD repeat TRM82 family | 0.540 |
| NDUFV3 | JAM2 | ENSP00000346196 | ENSP00000383376 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I | Junctional adhesion molecule B; May play a role in the processes of lymphocyte homing to secondary lymphoid organs; Belongs to the immunoglobulin superfamily | 0.529 |
| NDUFV3 | PKNOX1 | ENSP00000346196 | ENSP00000291547 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I | Homeobox protein PKNOX1; TALE class homeoboxes and pseudogenes | 0.539 |
| NDUFV3 | PTTG1IP | ENSP00000346196 | ENSP00000328325 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I | Pituitary tumor-transforming gene 1 protein-interacting protein; May facilitate PTTG1 nuclear translocation | 0.535 |
| NDUFV3 | SYNJ1 | ENSP00000346196 | ENSP00000409667 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I | Synaptojanin-1; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity); Belongs to the synaptojanin family | 0.469 |
| NDUFV3 | U2AF1L4 | ENSP00000346196 | ENSP00000292879 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I | Splicing factor U2AF 35 kDa subunit-like protein; U2 small nuclear RNA auxiliary factor 1 like 4; RNA binding motif containing | 0.468 |
| NDUFV3 | WDR4 | ENSP00000346196 | ENSP00000381266 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit; Belongs to the WD repeat TRM82 family | 0.579 |
| PKNOX1 | JAM2 | ENSP00000291547 | ENSP00000383376 | Homeobox protein PKNOX1; TALE class homeoboxes and pseudogenes | Junctional adhesion molecule B; May play a role in the processes of lymphocyte homing to secondary lymphoid organs; Belongs to the immunoglobulin superfamily | 0.573 |
