| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGEF10 | CLN8 | ENSP00000340297 | ENSP00000328182 | Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves; Rho guanine nucleotide exchange factors | Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death; TLC domain containing | 0.716 |
| CLN3 | CLN5 | ENSP00000454229 | ENSP00000366673 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | 0.910 |
| CLN3 | CLN6 | ENSP00000454229 | ENSP00000249806 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | CLN6, transmembrane ER protein | 0.895 |
| CLN3 | CLN8 | ENSP00000454229 | ENSP00000328182 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death; TLC domain containing | 0.870 |
| CLN3 | DNAJC5 | ENSP00000454229 | ENSP00000354111 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity); DNAJ heat shock proteins | 0.718 |
| CLN3 | KCTD7 | ENSP00000454229 | ENSP00000275532 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons | 0.697 |
| CLN3 | MFSD8 | ENSP00000454229 | ENSP00000296468 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily | 0.846 |
| CLN3 | PPT1 | ENSP00000454229 | ENSP00000394863 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons; Belongs to the palmitoyl-protein thioesterase family | 0.907 |
| CLN3 | TPP1 | ENSP00000454229 | ENSP00000299427 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity) | 0.766 |
| CLN5 | CLN3 | ENSP00000366673 | ENSP00000454229 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | 0.910 |
| CLN5 | CLN6 | ENSP00000366673 | ENSP00000249806 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | CLN6, transmembrane ER protein | 0.934 |
| CLN5 | CLN8 | ENSP00000366673 | ENSP00000328182 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death; TLC domain containing | 0.899 |
| CLN5 | DNAJC5 | ENSP00000366673 | ENSP00000354111 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity); DNAJ heat shock proteins | 0.748 |
| CLN5 | ENSG00000261832 | ENSP00000366673 | ENSP00000485589 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | Battenin isoform d | 0.918 |
| CLN5 | KCTD7 | ENSP00000366673 | ENSP00000275532 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons | 0.716 |
| CLN5 | MFSD8 | ENSP00000366673 | ENSP00000296468 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily | 0.837 |
| CLN5 | PPT1 | ENSP00000366673 | ENSP00000394863 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons; Belongs to the palmitoyl-protein thioesterase family | 0.835 |
| CLN5 | TPP1 | ENSP00000366673 | ENSP00000299427 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity) | 0.827 |
| CLN6 | CLN3 | ENSP00000249806 | ENSP00000454229 | CLN6, transmembrane ER protein | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes | 0.895 |
| CLN6 | CLN5 | ENSP00000249806 | ENSP00000366673 | CLN6, transmembrane ER protein | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane | 0.934 |
