| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSG00000253117 | OTOP3 | ENSP00000254627 | ENSP00000328090 | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity | Otopetrin-3; Otopetrin 3 | 0.542 |
| ENSG00000253117 | OTOP3 | ENSP00000262283 | ENSP00000328090 | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | Otopetrin-3; Otopetrin 3 | 0.542 |
| NR2C1 | OTOP3 | ENSP00000333275 | ENSP00000328090 | Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5’-AGGTCA-3’ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] | Otopetrin-3; Otopetrin 3 | 0.592 |
| NR2C1 | PDE8A | ENSP00000333275 | ENSP00000311453 | Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5’-AGGTCA-3’ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 ’Ser- 259’ inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | 0.601 |
| NR2C1 | RARRES2 | ENSP00000333275 | ENSP00000418009 | Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5’-AGGTCA-3’ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] | Retinoic acid receptor responder protein 2; Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an i [...] | 0.449 |
| NR2C1 | RBP3 | ENSP00000333275 | ENSP00000463151 | Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5’-AGGTCA-3’ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] | Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina | 0.484 |
| NR2C1 | RGR | ENSP00000333275 | ENSP00000352427 | Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5’-AGGTCA-3’ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] | RPE-retinal G protein-coupled receptor; Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism; Opsin receptors | 0.524 |
| OR51G2 | OTOP3 | ENSP00000322593 | ENSP00000328090 | Olfactory receptor 51G2; Odorant receptor; Olfactory receptors, family 51 | Otopetrin-3; Otopetrin 3 | 0.590 |
| OTOP3 | ENSG00000253117 | ENSP00000328090 | ENSP00000254627 | Otopetrin-3; Otopetrin 3 | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity | 0.542 |
| OTOP3 | ENSG00000253117 | ENSP00000328090 | ENSP00000262283 | Otopetrin-3; Otopetrin 3 | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | 0.542 |
| OTOP3 | NR2C1 | ENSP00000328090 | ENSP00000333275 | Otopetrin-3; Otopetrin 3 | Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5’-AGGTCA-3’ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] | 0.592 |
| OTOP3 | OR51G2 | ENSP00000328090 | ENSP00000322593 | Otopetrin-3; Otopetrin 3 | Olfactory receptor 51G2; Odorant receptor; Olfactory receptors, family 51 | 0.590 |
| OTOP3 | PDE8A | ENSP00000328090 | ENSP00000311453 | Otopetrin-3; Otopetrin 3 | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 ’Ser- 259’ inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | 0.655 |
| OTOP3 | RARRES2 | ENSP00000328090 | ENSP00000418009 | Otopetrin-3; Otopetrin 3 | Retinoic acid receptor responder protein 2; Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an i [...] | 0.562 |
| OTOP3 | RBP3 | ENSP00000328090 | ENSP00000463151 | Otopetrin-3; Otopetrin 3 | Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina | 0.531 |
| OTOP3 | RGR | ENSP00000328090 | ENSP00000352427 | Otopetrin-3; Otopetrin 3 | RPE-retinal G protein-coupled receptor; Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism; Opsin receptors | 0.601 |
| OTOP3 | RNF157 | ENSP00000328090 | ENSP00000269391 | Otopetrin-3; Otopetrin 3 | E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle; Ring finger proteins | 0.589 |
| OTOP3 | SRP68 | ENSP00000328090 | ENSP00000312066 | Otopetrin-3; Otopetrin 3 | Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function | 0.517 |
| PDE8A | NR2C1 | ENSP00000311453 | ENSP00000333275 | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 ’Ser- 259’ inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5’-AGGTCA-3’ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiatio [...] | 0.601 |
| PDE8A | OTOP3 | ENSP00000311453 | ENSP00000328090 | High affinity cAMP-specific and IBMX-insensitive 3’,5’-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 ’Ser- 259’ inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine; Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily | Otopetrin-3; Otopetrin 3 | 0.655 |
