node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPP | BYSL | ENSP00000375881 | ENSP00000230340 | Alkaline phosphatase, placental | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family | 0.446 |
ALPP | C6orf58 | ENSP00000375881 | ENSP00000328069 | Alkaline phosphatase, placental | Protein LEG1 homolog; May be involved in early liver development | 0.642 |
BPIFB1 | BPIFB2 | ENSP00000253354 | ENSP00000170150 | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold containing family B member 2; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | 0.746 |
BPIFB1 | C6orf58 | ENSP00000253354 | ENSP00000328069 | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | Protein LEG1 homolog; May be involved in early liver development | 0.453 |
BPIFB2 | BPIFB1 | ENSP00000170150 | ENSP00000253354 | BPI fold containing family B member 2; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.746 |
BPIFB2 | C6orf58 | ENSP00000170150 | ENSP00000328069 | BPI fold containing family B member 2; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | Protein LEG1 homolog; May be involved in early liver development | 0.457 |
BYSL | ALPP | ENSP00000230340 | ENSP00000375881 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family | Alkaline phosphatase, placental | 0.446 |
BYSL | C6orf58 | ENSP00000230340 | ENSP00000328069 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family | Protein LEG1 homolog; May be involved in early liver development | 0.476 |
C6orf58 | ALPP | ENSP00000328069 | ENSP00000375881 | Protein LEG1 homolog; May be involved in early liver development | Alkaline phosphatase, placental | 0.642 |
C6orf58 | BPIFB1 | ENSP00000328069 | ENSP00000253354 | Protein LEG1 homolog; May be involved in early liver development | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.453 |
C6orf58 | BPIFB2 | ENSP00000328069 | ENSP00000170150 | Protein LEG1 homolog; May be involved in early liver development | BPI fold containing family B member 2; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | 0.457 |
C6orf58 | BYSL | ENSP00000328069 | ENSP00000230340 | Protein LEG1 homolog; May be involved in early liver development | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family | 0.476 |
C6orf58 | MAP3K11 | ENSP00000328069 | ENSP00000309597 | Protein LEG1 homolog; May be involved in early liver development | Mitogen-activated protein kinase kinase kinase 11; Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | 0.652 |
C6orf58 | PKN2 | ENSP00000328069 | ENSP00000359552 | Protein LEG1 homolog; May be involved in early liver development | Serine/threonine-protein kinase N2; PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the re [...] | 0.476 |
C6orf58 | SNW1 | ENSP00000328069 | ENSP00000261531 | Protein LEG1 homolog; May be involved in early liver development | SNW domain-containing protein 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coac [...] | 0.498 |
C6orf58 | SPAG1 | ENSP00000328069 | ENSP00000373450 | Protein LEG1 homolog; May be involved in early liver development | Sperm-associated antigen 1; May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity; Tetratricopeptide repeat domain containing | 0.482 |
C6orf58 | TOMM20L | ENSP00000328069 | ENSP00000354204 | Protein LEG1 homolog; May be involved in early liver development | TOMM20-like protein 1; Translocase of outer mitochondrial membrane 20 like | 0.447 |
C6orf58 | USB1 | ENSP00000328069 | ENSP00000219281 | Protein LEG1 homolog; May be involved in early liver development | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3’ end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3’ end-terminated with a 2’,3’-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family | 0.513 |
MAP3K11 | C6orf58 | ENSP00000309597 | ENSP00000328069 | Mitogen-activated protein kinase kinase kinase 11; Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | Protein LEG1 homolog; May be involved in early liver development | 0.652 |
MAP3K11 | SNW1 | ENSP00000309597 | ENSP00000261531 | Mitogen-activated protein kinase kinase kinase 11; Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily | SNW domain-containing protein 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coac [...] | 0.569 |