| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANGPTL3 | TNFAIP8L3 | ENSP00000360170 | ENSP00000328016 | Angiopoietin-related protein 3; Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LP [...] | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling; Belongs to the TNFAIP8 family | 0.492 |
| DMXL2 | KDELC2 | ENSP00000441858 | ENSP00000315386 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | 0.451 |
| DMXL2 | LYSMD2 | ENSP00000441858 | ENSP00000267838 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | 0.668 |
| DMXL2 | PRR16 | ENSP00000441858 | ENSP00000385118 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration | 0.502 |
| DMXL2 | SCNM1 | ENSP00000441858 | ENSP00000357901 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.405 |
| DMXL2 | SLC35F2 | ENSP00000441858 | ENSP00000436785 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | Solute carrier family 35 member F2; Putative solute transporter | 0.476 |
| DMXL2 | TNFAIP8L3 | ENSP00000441858 | ENSP00000328016 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling; Belongs to the TNFAIP8 family | 0.517 |
| ELMOD1 | KDELC2 | ENSP00000265840 | ENSP00000315386 | ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | 0.600 |
| ELMOD1 | SLC35F2 | ENSP00000265840 | ENSP00000436785 | ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family | Solute carrier family 35 member F2; Putative solute transporter | 0.548 |
| ELMOD1 | TNFAIP8L3 | ENSP00000265840 | ENSP00000328016 | ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling; Belongs to the TNFAIP8 family | 0.482 |
| EXPH5 | KDELC2 | ENSP00000265843 | ENSP00000315386 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | 0.684 |
| EXPH5 | SLC35F2 | ENSP00000265843 | ENSP00000436785 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking | Solute carrier family 35 member F2; Putative solute transporter | 0.499 |
| EXPH5 | TNFAIP8L3 | ENSP00000265843 | ENSP00000328016 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling; Belongs to the TNFAIP8 family | 0.466 |
| KDELC2 | DMXL2 | ENSP00000315386 | ENSP00000441858 | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | 0.451 |
| KDELC2 | ELMOD1 | ENSP00000315386 | ENSP00000265840 | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family | 0.600 |
| KDELC2 | EXPH5 | ENSP00000315386 | ENSP00000265843 | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking | 0.684 |
| KDELC2 | SLC35F2 | ENSP00000315386 | ENSP00000436785 | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | Solute carrier family 35 member F2; Putative solute transporter | 0.558 |
| KDELC2 | TNFAIP8L3 | ENSP00000315386 | ENSP00000328016 | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling; Belongs to the TNFAIP8 family | 0.551 |
| LYSMD2 | DMXL2 | ENSP00000267838 | ENSP00000441858 | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity); Deafness associated genes | 0.668 |
| LYSMD2 | TNFAIP8L3 | ENSP00000267838 | ENSP00000328016 | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling; Belongs to the TNFAIP8 family | 0.530 |
