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  • 11.0 [archived version]
STRINGSTRING
ENSG00000239810 ENSG00000239810 RNF151 RNF151 PRAMEF12 PRAMEF12 PRAMEF14 PRAMEF14 KHDC1L KHDC1L TRIM49 TRIM49 BBOX1 BBOX1 PRAMEF2 PRAMEF2 ENSG00000239810 ENSG00000239810 SKP2 SKP2 CKS1B CKS1B
"TRIM49" - Tripartite motif containing 49 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRIM49Tripartite motif containing 49; Ring finger proteins (452 aa)    
Predicted Functional Partners:
CKS1B
Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function (79 aa)
        
      0.691
RNF151
RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins (245 aa)
            
  0.654
BBOX1
Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family (387 aa)
            
  0.626
PRAMEF14
PRAME family member 14 (474 aa)
      
   
  0.601
PRAMEF12
PRAME family member 12; Belongs to the PRAME family (483 aa)
      
   
  0.586
ENSG00000239810
PRAME family member 11 (478 aa)
      
   
  0.568
KHDC1L
Putative KHDC1-like protein; KH domain containing 1 like; Belongs to the KHDC1 family (128 aa)
            
  0.567
SKP2
S-phase kinase-associated protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of T [...] (424 aa)
        
      0.546
ENSG00000239810
PRAME family member 11 (436 aa)
            
  0.538
PRAMEF2
PRAME family member 2; Belongs to the PRAME family (474 aa)
      
   
  0.534
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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