| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACP5 | PAPL | ENSP00000468767 | ENSP00000327557 | Tartrate-resistant acid phosphatase type 5; Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | 0.837 |
| ACP5 | PHTF1 | ENSP00000468767 | ENSP00000358617 | Tartrate-resistant acid phosphatase type 5; Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | Putative homeodomain transcription factor 1; May play a role in transcription regulation | 0.538 |
| ACP6 | PAPL | ENSP00000463574 | ENSP00000327557 | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | 0.559 |
| CA9 | PAPL | ENSP00000367608 | ENSP00000327557 | Carbonic anhydrase 9; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia; Belongs to the alpha-carbonic anhydrase family | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | 0.515 |
| LIN7B | MEIOB | ENSP00000221459 | ENSP00000390778 | Protein lin-7 homolog B; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may funct [...] | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] | 0.473 |
| LIN7B | PAPL | ENSP00000221459 | ENSP00000327557 | Protein lin-7 homolog B; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may funct [...] | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | 0.559 |
| MEIOB | LIN7B | ENSP00000390778 | ENSP00000221459 | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] | Protein lin-7 homolog B; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may funct [...] | 0.473 |
| MEIOB | PAPL | ENSP00000390778 | ENSP00000327557 | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | 0.483 |
| MIOX | PAPL | ENSP00000216075 | ENSP00000327557 | Myo-inositol oxygenase | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | 0.545 |
| MRAS | PAPL | ENSP00000289104 | ENSP00000327557 | Ras-related protein M-Ras; May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway; Belongs to the small GTPase superfamily. Ras family | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | 0.618 |
| NIF3L1 | PAPL | ENSP00000386394 | ENSP00000327557 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | 0.519 |
| PAPL | ACP5 | ENSP00000327557 | ENSP00000468767 | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | Tartrate-resistant acid phosphatase type 5; Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | 0.837 |
| PAPL | ACP6 | ENSP00000327557 | ENSP00000463574 | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14-0), monounsaturated oleate (C18-1) or palmitate (C16-0), and lower activity with C18-0 and C6-0 lysophosphatidic acid | 0.559 |
| PAPL | CA9 | ENSP00000327557 | ENSP00000367608 | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | Carbonic anhydrase 9; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia; Belongs to the alpha-carbonic anhydrase family | 0.515 |
| PAPL | LIN7B | ENSP00000327557 | ENSP00000221459 | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | Protein lin-7 homolog B; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may funct [...] | 0.559 |
| PAPL | MEIOB | ENSP00000327557 | ENSP00000390778 | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] | 0.483 |
| PAPL | MIOX | ENSP00000327557 | ENSP00000216075 | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | Myo-inositol oxygenase | 0.545 |
| PAPL | MRAS | ENSP00000327557 | ENSP00000289104 | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | Ras-related protein M-Ras; May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway; Belongs to the small GTPase superfamily. Ras family | 0.618 |
| PAPL | NIF3L1 | ENSP00000327557 | ENSP00000386394 | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | 0.519 |
| PAPL | PHTF1 | ENSP00000327557 | ENSP00000358617 | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family | Putative homeodomain transcription factor 1; May play a role in transcription regulation | 0.621 |
