| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYSTM1 | HIGD2A | ENSP00000261811 | ENSP00000274787 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 | HIG1 domain family member 2A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes | 0.452 |
| CYSTM1 | SIMC1 | ENSP00000261811 | ENSP00000342075 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 | SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1 | 0.420 |
| CYSTM1 | THG1L | ENSP00000261811 | ENSP00000231198 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis | 0.445 |
| CYSTM1 | WDR55 | ENSP00000261811 | ENSP00000351100 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 | WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity); WD repeat domain containing | 0.440 |
| CYSTM1 | ZNF354B | ENSP00000261811 | ENSP00000327143 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 | Zinc finger protein 354B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.441 |
| HIGD2A | CYSTM1 | ENSP00000274787 | ENSP00000261811 | HIG1 domain family member 2A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 | 0.452 |
| HIGD2A | SIMC1 | ENSP00000274787 | ENSP00000342075 | HIG1 domain family member 2A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes | SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1 | 0.418 |
| HIGD2A | THG1L | ENSP00000274787 | ENSP00000231198 | HIG1 domain family member 2A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis | 0.441 |
| HIGD2A | WDR55 | ENSP00000274787 | ENSP00000351100 | HIG1 domain family member 2A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes | WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity); WD repeat domain containing | 0.426 |
| HIGD2A | ZNF354B | ENSP00000274787 | ENSP00000327143 | HIG1 domain family member 2A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes | Zinc finger protein 354B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.430 |
| MFSD2A | ZNF354B | ENSP00000361895 | ENSP00000327143 | Sodium-dependent lysophosphatidylcholine symporter 1; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fa [...] | Zinc finger protein 354B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.439 |
| PCYOX1L | THG1L | ENSP00000274569 | ENSP00000231198 | Prenylcysteine oxidase-like; Probable oxidoreductase; Belongs to the prenylcysteine oxidase family | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis | 0.449 |
| PCYOX1L | WDR55 | ENSP00000274569 | ENSP00000351100 | Prenylcysteine oxidase-like; Probable oxidoreductase; Belongs to the prenylcysteine oxidase family | WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity); WD repeat domain containing | 0.418 |
| PCYOX1L | ZNF354B | ENSP00000274569 | ENSP00000327143 | Prenylcysteine oxidase-like; Probable oxidoreductase; Belongs to the prenylcysteine oxidase family | Zinc finger protein 354B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.420 |
| RNF145 | THG1L | ENSP00000430955 | ENSP00000231198 | Ring finger protein 145 | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis | 0.420 |
| RNF145 | WDR55 | ENSP00000430955 | ENSP00000351100 | Ring finger protein 145 | WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity); WD repeat domain containing | 0.400 |
| RNF145 | ZNF354B | ENSP00000430955 | ENSP00000327143 | Ring finger protein 145 | Zinc finger protein 354B; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.425 |
| SIMC1 | CYSTM1 | ENSP00000342075 | ENSP00000261811 | SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 | 0.420 |
| SIMC1 | HIGD2A | ENSP00000342075 | ENSP00000274787 | SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1 | HIG1 domain family member 2A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes | 0.418 |
| SIMC1 | THG1L | ENSP00000342075 | ENSP00000231198 | SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1 | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis | 0.447 |
