node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HIBCH | ORMDL1 | ENSP00000352706 | ENSP00000326869 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | 0.713 |
HIBCH | PMS1 | ENSP00000352706 | ENSP00000406490 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | PMS1 protein homolog 1; Probably involved in the repair of mismatches in DNA | 0.710 |
ORM1 | ORM2 | ENSP00000259396 | ENSP00000394936 | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family | Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Lipocalins | 0.999 |
ORM1 | ORMDL1 | ENSP00000259396 | ENSP00000326869 | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | 0.890 |
ORM1 | SPTLC2 | ENSP00000259396 | ENSP00000216484 | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family | 0.411 |
ORM2 | ORM1 | ENSP00000394936 | ENSP00000259396 | Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Lipocalins | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family | 0.999 |
ORM2 | ORMDL1 | ENSP00000394936 | ENSP00000326869 | Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Lipocalins | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | 0.904 |
ORMDL1 | HIBCH | ENSP00000326869 | ENSP00000352706 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | 0.713 |
ORMDL1 | ORM1 | ENSP00000326869 | ENSP00000259396 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Belongs to the calycin superfamily. Lipocalin family | 0.890 |
ORMDL1 | ORM2 | ENSP00000326869 | ENSP00000394936 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction; Lipocalins | 0.904 |
ORMDL1 | PMS1 | ENSP00000326869 | ENSP00000406490 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | PMS1 protein homolog 1; Probably involved in the repair of mismatches in DNA | 0.718 |
ORMDL1 | SFT2D2 | ENSP00000326869 | ENSP00000271375 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | Vesicle transport protein SFT2B; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex | 0.764 |
ORMDL1 | SPTLC1 | ENSP00000326869 | ENSP00000262554 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability t [...] | 0.920 |
ORMDL1 | SPTLC2 | ENSP00000326869 | ENSP00000216484 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family | 0.845 |
ORMDL1 | SPTLC3 | ENSP00000326869 | ENSP00000381968 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | Serine palmitoyltransferase 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.718 |
ORMDL1 | SPTSSA | ENSP00000326869 | ENSP00000298130 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2- SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16- CoA as substrates, with a slight preference for C14-CoA | 0.833 |
ORMDL1 | SPTSSB | ENSP00000326869 | ENSP00000352097 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | Serine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction | 0.742 |
PMS1 | HIBCH | ENSP00000406490 | ENSP00000352706 | PMS1 protein homolog 1; Probably involved in the repair of mismatches in DNA | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | 0.710 |
PMS1 | ORMDL1 | ENSP00000406490 | ENSP00000326869 | PMS1 protein homolog 1; Probably involved in the repair of mismatches in DNA | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | 0.718 |
SFT2D2 | ORMDL1 | ENSP00000271375 | ENSP00000326869 | Vesicle transport protein SFT2B; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex | ORM1-like protein 1; Negative regulator of sphingolipid synthesis | 0.764 |