node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC5L | SMCHD1 | ENSP00000360532 | ENSP00000326603 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells | 0.980 |
CDC5L | TSG101 | ENSP00000360532 | ENSP00000251968 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding [...] | 0.980 |
DUX4 | DUX4L1 | ENSP00000458065 | ENSP00000451207 | Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family | Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes | 0.800 |
DUX4 | DUX4L7 | ENSP00000458065 | ENSP00000451411 | Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family | Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes | 0.801 |
DUX4 | DUX4L8 | ENSP00000458065 | ENSP00000485452 | Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family | Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes | 0.801 |
DUX4 | SMCHD1 | ENSP00000458065 | ENSP00000326603 | Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family | Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells | 0.860 |
DUX4L1 | DUX4 | ENSP00000451207 | ENSP00000458065 | Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes | Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family | 0.800 |
DUX4L1 | DUX4L7 | ENSP00000451207 | ENSP00000451411 | Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes | Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes | 0.808 |
DUX4L1 | DUX4L8 | ENSP00000451207 | ENSP00000485452 | Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes | Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes | 0.815 |
DUX4L1 | SMCHD1 | ENSP00000451207 | ENSP00000326603 | Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes | Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells | 0.860 |
DUX4L7 | DUX4 | ENSP00000451411 | ENSP00000458065 | Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes | Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family | 0.801 |
DUX4L7 | DUX4L1 | ENSP00000451411 | ENSP00000451207 | Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes | Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes | 0.808 |
DUX4L7 | DUX4L8 | ENSP00000451411 | ENSP00000485452 | Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes | Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes | 0.814 |
DUX4L7 | SMCHD1 | ENSP00000451411 | ENSP00000326603 | Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes | Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells | 0.840 |
DUX4L8 | DUX4 | ENSP00000485452 | ENSP00000458065 | Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes | Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family | 0.801 |
DUX4L8 | DUX4L1 | ENSP00000485452 | ENSP00000451207 | Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes | Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes | 0.815 |
DUX4L8 | DUX4L7 | ENSP00000485452 | ENSP00000451411 | Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes | Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes | 0.814 |
DUX4L8 | SMCHD1 | ENSP00000485452 | ENSP00000326603 | Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes | Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells | 0.839 |
MVB12A | SMCHD1 | ENSP00000324810 | ENSP00000326603 | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor; Belongs to the MVB12 family | Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells | 0.902 |
MVB12A | TSG101 | ENSP00000324810 | ENSP00000251968 | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor; Belongs to the MVB12 family | Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding [...] | 0.996 |