node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KDM3A | KDM3B | ENSP00000386660 | ENSP00000326563 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | 0.821 |
KDM3A | KDM4B | ENSP00000386660 | ENSP00000159111 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | Lysine-specific demethylase 4B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Only able to demethylate trimethylated H3 ’Lys-9’, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate; Lysine demethylases | 0.751 |
KDM3A | PPARG | ENSP00000386660 | ENSP00000287820 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.877 |
KDM3A | PRKACA | ENSP00000386660 | ENSP00000309591 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.804 |
KDM3A | PRKACB | ENSP00000386660 | ENSP00000359719 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] | 0.804 |
KDM3A | PRKACG | ENSP00000386660 | ENSP00000366488 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily | 0.804 |
KDM3A | SMARCB1 | ENSP00000386660 | ENSP00000263121 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric struct [...] | 0.696 |
KDM3A | SMARCC1 | ENSP00000386660 | ENSP00000254480 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | SWI/SNF complex subunit SMARCC1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF [...] | 0.705 |
KDM3A | SMARCC2 | ENSP00000386660 | ENSP00000267064 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | 0.663 |
KDM3A | SMARCD3 | ENSP00000386660 | ENSP00000262188 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- spe [...] | 0.658 |
KDM3B | KDM3A | ENSP00000326563 | ENSP00000386660 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | 0.821 |
KDM3B | KDM4B | ENSP00000326563 | ENSP00000159111 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | Lysine-specific demethylase 4B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Only able to demethylate trimethylated H3 ’Lys-9’, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate; Lysine demethylases | 0.698 |
KDM3B | PPARG | ENSP00000326563 | ENSP00000287820 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.800 |
KDM3B | PRKACA | ENSP00000326563 | ENSP00000309591 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.804 |
KDM3B | PRKACB | ENSP00000326563 | ENSP00000359719 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] | 0.804 |
KDM3B | PRKACG | ENSP00000326563 | ENSP00000366488 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily | 0.804 |
KDM3B | SMARCB1 | ENSP00000326563 | ENSP00000263121 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric struct [...] | 0.719 |
KDM3B | SMARCC1 | ENSP00000326563 | ENSP00000254480 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | SWI/SNF complex subunit SMARCC1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF [...] | 0.730 |
KDM3B | SMARCC2 | ENSP00000326563 | ENSP00000267064 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | 0.728 |
KDM3B | SMARCD3 | ENSP00000326563 | ENSP00000262188 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity; Lysine demethylases | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- spe [...] | 0.698 |