| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABHD1 | CABLES1 | ENSP00000326491 | ENSP00000256925 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) | 0.576 |
| ABHD1 | CABLES2 | ENSP00000326491 | ENSP00000279101 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | CDK5 and ABL1 enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition | 0.576 |
| ABHD1 | ENDOD1 | ENSP00000326491 | ENSP00000278505 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase | 0.658 |
| ABHD1 | FAM166A | ENSP00000326491 | ENSP00000344729 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | Protein FAM166A; Family with sequence similarity 166 member A | 0.514 |
| ABHD1 | FGF19 | ENSP00000326491 | ENSP00000294312 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | Fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4; Belongs to the heparin-binding growth factors family | 0.649 |
| ABHD1 | KIRREL | ENSP00000326491 | ENSP00000352138 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | Kin of IRRE-like protein 1; Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity); Belongs to the immunoglobulin superfamily | 0.508 |
| ABHD1 | OSBPL1A | ENSP00000326491 | ENSP00000320291 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | Oxysterol-binding protein-related protein 1; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol; Belongs to the OSBP family | 0.661 |
| ABHD1 | PREB | ENSP00000326491 | ENSP00000260643 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | Prolactin regulatory element-binding protein; Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER; WD repeat domain containing | 0.710 |
| ABHD1 | SNTG1 | ENSP00000326491 | ENSP00000429842 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | Gamma-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation; Belongs to the syntrophin family | 0.581 |
| ABHD1 | TEX38 | ENSP00000326491 | ENSP00000455854 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | Testis-expressed protein 38; Testis expressed 38 | 0.530 |
| CABLES1 | ABHD1 | ENSP00000256925 | ENSP00000326491 | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | 0.576 |
| CABLES1 | OSBPL1A | ENSP00000256925 | ENSP00000320291 | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) | Oxysterol-binding protein-related protein 1; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol; Belongs to the OSBP family | 0.633 |
| CABLES2 | ABHD1 | ENSP00000279101 | ENSP00000326491 | CDK5 and ABL1 enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | 0.576 |
| CABLES2 | OSBPL1A | ENSP00000279101 | ENSP00000320291 | CDK5 and ABL1 enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition | Oxysterol-binding protein-related protein 1; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol; Belongs to the OSBP family | 0.599 |
| ENDOD1 | ABHD1 | ENSP00000278505 | ENSP00000326491 | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | 0.658 |
| ENDOD1 | KIRREL | ENSP00000278505 | ENSP00000352138 | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase | Kin of IRRE-like protein 1; Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity); Belongs to the immunoglobulin superfamily | 0.523 |
| FAM166A | ABHD1 | ENSP00000344729 | ENSP00000326491 | Protein FAM166A; Family with sequence similarity 166 member A | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | 0.514 |
| FAM166A | TEX38 | ENSP00000344729 | ENSP00000455854 | Protein FAM166A; Family with sequence similarity 166 member A | Testis-expressed protein 38; Testis expressed 38 | 0.672 |
| FGF19 | ABHD1 | ENSP00000294312 | ENSP00000326491 | Fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4; Belongs to the heparin-binding growth factors family | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | 0.649 |
| FGF19 | PREB | ENSP00000294312 | ENSP00000260643 | Fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4; Belongs to the heparin-binding growth factors family | Prolactin regulatory element-binding protein; Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER; WD repeat domain containing | 0.499 |
