| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FRAS1 | FREM1 | ENSP00000326330 | ENSP00000412940 | Fraser extracellular matrix complex subunit 1 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family | 0.583 |
| FRAS1 | FREM2 | ENSP00000326330 | ENSP00000280481 | Fraser extracellular matrix complex subunit 1 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion | 0.883 |
| FRAS1 | FREM3 | ENSP00000326330 | ENSP00000332886 | Fraser extracellular matrix complex subunit 1 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion | 0.724 |
| FRAS1 | GRIP1 | ENSP00000326330 | ENSP00000381098 | Fraser extracellular matrix complex subunit 1 | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity); PDZ domain containing | 0.735 |
| FRAS1 | HMCN1 | ENSP00000326330 | ENSP00000271588 | Fraser extracellular matrix complex subunit 1 | Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration; Fibulins | 0.807 |
| FRAS1 | NPNT | ENSP00000326330 | ENSP00000389252 | Fraser extracellular matrix complex subunit 1 | Nephronectin; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity) | 0.598 |
| FRAS1 | PHIP | ENSP00000326330 | ENSP00000275034 | Fraser extracellular matrix complex subunit 1 | PH-interacting protein; Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti- apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization; Bromodomain containing | 0.562 |
| FRAS1 | PKDREJ | ENSP00000326330 | ENSP00000253255 | Fraser extracellular matrix complex subunit 1 | Polycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm; Belongs to the polycystin family | 0.562 |
| FRAS1 | SPATA25 | ENSP00000326330 | ENSP00000361597 | Fraser extracellular matrix complex subunit 1 | Spermatogenesis-associated protein 25; May play a role in spermatogenesis; Belongs to the SPATA25 family | 0.563 |
| FRAS1 | VWA2 | ENSP00000326330 | ENSP00000376708 | Fraser extracellular matrix complex subunit 1 | Von Willebrand factor A domain containing 2 | 0.688 |
| FREM1 | FRAS1 | ENSP00000412940 | ENSP00000326330 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family | Fraser extracellular matrix complex subunit 1 | 0.583 |
| FREM1 | FREM2 | ENSP00000412940 | ENSP00000280481 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion | 0.429 |
| FREM1 | GRIP1 | ENSP00000412940 | ENSP00000381098 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity); PDZ domain containing | 0.675 |
| FREM1 | HMCN1 | ENSP00000412940 | ENSP00000271588 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family | Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration; Fibulins | 0.722 |
| FREM1 | NPNT | ENSP00000412940 | ENSP00000389252 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family | Nephronectin; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity) | 0.549 |
| FREM1 | VWA2 | ENSP00000412940 | ENSP00000376708 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family | Von Willebrand factor A domain containing 2 | 0.583 |
| FREM2 | FRAS1 | ENSP00000280481 | ENSP00000326330 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion | Fraser extracellular matrix complex subunit 1 | 0.883 |
| FREM2 | FREM1 | ENSP00000280481 | ENSP00000412940 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family | 0.429 |
| FREM2 | FREM3 | ENSP00000280481 | ENSP00000332886 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion | 0.443 |
| FREM2 | GRIP1 | ENSP00000280481 | ENSP00000381098 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity); PDZ domain containing | 0.737 |
