• Version:
  • 11.0 [archived version]
STRINGSTRING
PCDHGA7 PCDHGA7 PCDHGB3 PCDHGB3 PCDHGA5 PCDHGA5 FAM19A5 FAM19A5 ZNF454 ZNF454 RMDN2 RMDN2 TMEM179 TMEM179 ZDHHC19 ZDHHC19 TRIM28 TRIM28 ZDHHC12 ZDHHC12 UQCRFS1 UQCRFS1
"ZNF454" - Zinc finger protein 454 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
ZNF454Zinc finger protein 454; May be involved in transcriptional regulation; Zinc fingers C2H2-type (522 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.905
UQCRFS1
Cytochrome b-c1 complex subunit Rieske, mitochondrial; Cytochrome b-c1 complex subunit Rieske, mitochondrial- Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity) (274 aa)
     
      0.804
RMDN2
Regulator of microtubule dynamics 2; Belongs to the RMDN family (573 aa)
           
  0.726
ZDHHC19
Probable palmitoyltransferase ZDHHC19; Zinc finger DHHC-type containing 19; Belongs to the DHHC palmitoyltransferase family (309 aa)
       
 
  0.644
PCDHGA7
Protocadherin gamma-A7; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (932 aa)
       
 
  0.542
PCDHGA5
Protocadherin gamma-A5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (931 aa)
       
 
  0.534
PCDHGB3
Protocadherin gamma-B3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (929 aa)
       
 
  0.522
TMEM179
Transmembrane protein 179; Belongs to the TMEM179 family (233 aa)
           
  0.512
FAM19A5
Protein FAM19A5; Family with sequence similarity 19 member A5, C-C motif chemokine like; Belongs to the FAM19/TAFA family (132 aa)
           
  0.502
ZDHHC12
Probable palmitoyltransferase ZDHHC12; Zinc finger DHHC-type containing 12; Belongs to the DHHC palmitoyltransferase family (267 aa)
       
 
  0.498
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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