node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BANP | RNF166 | ENSP00000376902 | ENSP00000326095 | Protein BANP; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 ’Ser-15’ phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity); Belongs to the BANP/SMAR1 family | Ring finger protein 166 | 0.503 |
CHD1L | RNF166 | ENSP00000358262 | ENSP00000326095 | Chromodomain-helicase-DNA-binding protein 1-like; DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding; Belongs to the SNF2/RAD54 helicase family | Ring finger protein 166 | 0.528 |
KLHL28 | RNF166 | ENSP00000379434 | ENSP00000326095 | Kelch-like protein 28; Kelch like family member 28; BTB domain containing | Ring finger protein 166 | 0.543 |
LRSAM1 | RNF114 | ENSP00000322937 | ENSP00000244061 | E3 ubiquitin-protein ligase LRSAM1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria- associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy); Ring finger proteins | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle’s G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis; Ring finger proteins | 0.903 |
LRSAM1 | RNF166 | ENSP00000322937 | ENSP00000326095 | E3 ubiquitin-protein ligase LRSAM1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria- associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy); Ring finger proteins | Ring finger protein 166 | 0.515 |
MAGEE2 | RNF166 | ENSP00000362457 | ENSP00000326095 | Melanoma-associated antigen E2; MAGE family member E2 | Ring finger protein 166 | 0.625 |
MAGEF1 | RNF166 | ENSP00000315064 | ENSP00000326095 | Melanoma-associated antigen F1; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex; MAGE family | Ring finger protein 166 | 0.477 |
PARP11 | RNF114 | ENSP00000228820 | ENSP00000244061 | Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle’s G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis; Ring finger proteins | 0.831 |
PARP11 | RNF166 | ENSP00000228820 | ENSP00000326095 | Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases | Ring finger protein 166 | 0.787 |
PARP12 | RNF114 | ENSP00000263549 | ENSP00000244061 | poly(ADP-ribose) polymerase family member 12 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle’s G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis; Ring finger proteins | 0.694 |
PARP12 | RNF166 | ENSP00000263549 | ENSP00000326095 | poly(ADP-ribose) polymerase family member 12 | Ring finger protein 166 | 0.538 |
RNF114 | LRSAM1 | ENSP00000244061 | ENSP00000322937 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle’s G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis; Ring finger proteins | E3 ubiquitin-protein ligase LRSAM1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria- associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy); Ring finger proteins | 0.903 |
RNF114 | PARP11 | ENSP00000244061 | ENSP00000228820 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle’s G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis; Ring finger proteins | Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity; Poly(ADP-ribose) polymerases | 0.831 |
RNF114 | PARP12 | ENSP00000244061 | ENSP00000263549 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle’s G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis; Ring finger proteins | poly(ADP-ribose) polymerase family member 12 | 0.694 |
RNF114 | RNF166 | ENSP00000244061 | ENSP00000326095 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle’s G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis; Ring finger proteins | Ring finger protein 166 | 0.808 |
RNF166 | BANP | ENSP00000326095 | ENSP00000376902 | Ring finger protein 166 | Protein BANP; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 ’Ser-15’ phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity); Belongs to the BANP/SMAR1 family | 0.503 |
RNF166 | CHD1L | ENSP00000326095 | ENSP00000358262 | Ring finger protein 166 | Chromodomain-helicase-DNA-binding protein 1-like; DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding; Belongs to the SNF2/RAD54 helicase family | 0.528 |
RNF166 | KLHL28 | ENSP00000326095 | ENSP00000379434 | Ring finger protein 166 | Kelch-like protein 28; Kelch like family member 28; BTB domain containing | 0.543 |
RNF166 | LRSAM1 | ENSP00000326095 | ENSP00000322937 | Ring finger protein 166 | E3 ubiquitin-protein ligase LRSAM1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria- associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy); Ring finger proteins | 0.515 |
RNF166 | MAGEE2 | ENSP00000326095 | ENSP00000362457 | Ring finger protein 166 | Melanoma-associated antigen E2; MAGE family member E2 | 0.625 |